Curriculum Vitae

Curriculum Vitae Name: Boonsong Ongphiphadhanakul Sex: Male Date of Birth 31 December 1958 Affiliation Division of Endocrinology and Metabolism...

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Curriculum Vitae Name: Boonsong Ongphiphadhanakul Sex: Male Date of Birth 31 December 1958 Affiliation Division of Endocrinology and Metabolism Department of Medicine Faculty of Medicine, Ramathibodi Hospital Mahidol University Bangkok,Thailand

Education & Work Experience 1981 Bachelor of Science, first class honors, Mahidol University, Thailand. 1983 Master of Medicine, first class honors, Mahidol University, Thailand. 1983-1984 Intern, Ramathibodi Hospital, Mahidol University, Thailand. 1984-1986 Chief, Out-Patient Department, Korat Psychiatric Hospital, Nakornratchasima, Thailand. 1986-1989 Resident in Internal Medicine, Ramathibodi Hospital, Mahidol Universiy, Thailand. 1989-1990 Fellow in Endocrinology, Division of Endocrinology and Metabolism, Ramathibodi Hospital, Mahidol University, Thailand. 1990-1993 Fellow in Endocrinology, Division of Endocrinology and Metabolism, University of Massachusetts Medical School, Worcester, MA, U.S.A. 1993-1995 Instructor, Division of Endocrinology and Metabolism, Department of Medicine, Ramathibodi Hospital, Mahidol University, Thailand. 1995-1998 Assistant Professor, Division of Endocrinology and Metabolism, Department of Medicine, Ramathibodi Hospital, Mahidol University, Thailand. 1998-2000 Associate Professor, Division of Endocrinology and Metabolism, Department of Medicine, Ramathibodi Hospital, Mahidol University, Thailand. 1999 Master of Business Administration, Chulalongkorn University, Thailand. 2000 Certificate, Erasmus Summer Programme on Quantitative Medical Research, Erasmus University, Rotterdam, the Netherlands 2001-2002 Assistant Dean for Academic and Research Affairs, Faculty of Medicine, Ramathibodi Hospital, Mahidol University. 2001-present Professor, Division of Endocrinology and Metabolism, Department of Medicine, Ramathibodi Hospital, Mahidol University, Thailand. 2002-2008 Associate Dean for Research Affair, Faculty of Medicine, Ramathibodi Hospital, Mahidol University 2003-2006 Thailand Research Fund Senior Research Scholar 2005 Recipeint of Thailand's Outstanding Scientist Award 2007-present C11 Professor, Division of Endocrinology and Metabolism, Department of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.

2008-present Chief, Division of Endocrinology and Metabolism, Department of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.

Bibliography 1. Ongphiphadhanakul B, Puavilai G, Pensuwan S, Rajatanavin R. Causes of death in diabetics at Ramathibodi Hospital. Ramathibodi Medical Journal 1990;13:7678. 2. Jootar S, Chuncharunee S, Ongphiphadhanakul B, Atichartakarn V. Multivariate analysis of prognostic factors in chronic myelogenous leukemia. Journal of the Medical Association of Thailand 1990;73:662-669. 3. Kaojarern S, Ongphiphadhanakul B. Predicting outcomes in paraquat poisonings. Veterinary and Human Toxicology 1991;33:115-118. 4. Ongphiphadhanakul B, Rajatanavin R. Diabetes insipidus: another cause of hormonal hyperthermia. Journal of the Medical Association of Thailand 1992;75:127-132. 5. Ongphiphadhanakul B, Rajatanavin R, Chiemchanya S, Chailurkit L, Kongsuksai A, Isarangkul Na Ayuthya WI. Systematic inclusion of clinical and laboratory data improves diagnostic accuracy of fine-needle aspiration biopsy in solitary thyroid nodules. Acta Endocrinologica 1992;126:233-237. 6. Ongphiphadhanakul B, Ebner SA, Fang SL, Lombardi A, Baran DT, Braverman LE. 1,25-Dihydroxycholecalciferol modulates 3H-thymidine incorporation in FRTL5 cells. Jounal of Cellular Biochemistry 1992;49:304-309. 7. Ongphiphadhanakul B, Alex S, Braverman LE, Baran DT. Excessive L-thyroxine therapy decreases femoral bone mineral densities in the male rat: effect of hypogonadism and calcitonin. Journal of Bone and Mineral Research 1992;7:1227-31. 8. Ongphiphadhanakul B, Jenis LG, Braverman LE, Alex S, Stein GS, Lian JB, Baran DT. Etidronate inhibits the thyroid hormone-induced bone loss in rats assessed by bone mineral density and messenger ribonucleic acid markers of osteoblast and osteoclast function. Endocrinology 1993;133:2502-2507. 9. Ongphiphadhanakul B, Fang SL, Tang KT, Patwandhan NA, Braverman LE. Tumor necrosis factor-α decreases thyrotropin-induced 5'-deiodinase activity in FRTL-5 thyroid cells. European Journal of Endocrinology 1994;130:502-507. 10. Jenis LG, Ongphiphadhanakul B, Braverman LE, Stein GS, Lian JB, Lew R, Baran DT. Responsiveness of gene expression markers of osteoblastic and osteoclastic activity to calcitoinin in the appendicular and axial skeletons ot the rat in vivo. Calcified Tissue International 1994;54:511-515. 11. Ongphiphadhanakul B, Rajatanavin R, Chailurkit L, Piaseu N, Teerarungsikul K, Sirisriro R, Komindr S, Puavilai G. Serum testosterone and its relation to bone mineral density and body composition in normal males. Clinical Endocrinology 1995;43:727-733. 12. Suwanwalaikorn S, Ongphiphadhanakul B, Braverman LE, Baran DT. Differential responses of femoral and vertebral bones to long-term excessive L-thyroxine adminstration in adult rats. European Journal of Endocrinology 1996;134:655659. 13. Chailurkit L, Rajatanavin R, Teerarungsikul K, Ongphiphadhanakul B, Puavilai G. Serum vitamin D, parathyroid hormone and biochemical markers of bone turnover in normal Thai subjects. Journal of the Medical Association of Thailand. 1996; 79:499-504. 14. Ongphiphadhanakul B, Puavilai G, Rajatanavin R. Effect of TSH-suppressive doses of levothyroxine on bone mineral density in Thai women. Journal of the Medical Association of Thailand 1996;79:563-567. 15. Ongphiphadhanakul B, Rajatanavin R, Chailurkit L, Piaseu N, Teerarungsijul K, Sirisriro R, Komindr S, Pauvilai G. Prediction of low bone mineral density in

postmenopausal women by artificial neural network model compared to logistic regresssion model. Journal of the Medical Association of Thailand 1997;80:50815. 16. Ongphiphadhanakul B, Rajatanavin R, Chanprasertyothin S, Chailurkit L, Piaseu N, Teerarungsikul K, Sirisriro R. Vitamin D receptor gene polymorphism is associated with urinary calcium excretion but not with bone mineral density in postmenopausal women. Journal of Endocrinological Investigation 1997;20:5926. 17. Boonsarngsuk W, Charoenpan P, Ongphiphadhanakul B, Sirisriro R. Effects of longterm inhaled steroids on bone density in Thai asthmatics. Internal Medicine 1997;13:58-61. 18. Ongphiphadhanakul B, Piaseu N, Chailurkit L, Rajatanavin R. Suppression of bone resorption in early postmenopausal women by intranasal salmon calcitonin in relation to dosage and basal bone turnover. Calcified Tissue International 1998;62:379-82. 19. Vongterapak S, Dahlan W, Nakasatien S, Anuntakulnatee T, Suppanich M, Kittipoom W, Surasingchaidet C, Tamwiwat C, Tepkasetkul M, Bunnag P, Ongphiphadhanakul B, Rajatanavin R, Himathongkam T. Impediment of the progressions of microalbuminuria and hyperlipidemia in normotensive type 2 diabetes by low-dose ramipril. Journal of the Medical Association of Thailand 1998;81:671-681. 20. Ongphiphadhanakul B, Rajatanavin R, Chanprasertyothin S, Piaseu N, Chailurkit L, Sirisriro R, Komindr S. Estrogen receptor gene polymorphism is associated with bone mineral density in premenopausal women but not in postmenopausal women. Journal of Endocrinological Investigation. 1998;21:487-93. 21. Ongphiphadhanakul B, Chanprasertyothin S, Piaseu N, Chansirikanjana S, Puavilai G, Rajatanavin R Change in body weight after hormone replacement therapy in postmenopausal women is dependent on basal circulating leptin. Maturitas 1998;30:283-8 22. Ongphiphadhanakul B, Rajatanavin R, Chanprasertyothin S, Piaseu N, Chailurkit L. Serum oestradiol and oestrogen-receptor gene polymorphism are associated with bone mineral density independently of serum testosterone in normal males. Clinical Endocrinology 1998;49:803-809. 23. Reutrakul S, Ongphiphadhanakul B, Piaseu N, Krittiyawong S, Chanprasertyothin S, Bunnag P, Rajatanavin R. The effects of oestrogen exposure on bone mass in male to female transsexuals. Clinical Endocrinology 1998;49:811-814. 24. Ongphiphadhanakul B, Rajatanavin R, Chanprasertyothin S, Piaseu N, Chailurkit L, Komindr S, Bunnag P, Puavilai G. Relation of beta3-adrenergic receptor gene mutation to total body fat but not percent body fat and insulin levels in Thais. Metabolism 1999;48:564-567. 25. Ongphiphadhanakul B, Rajatanavin R, Chanprasertyothin S, Piaseu N, Chailurkit L. Serum leptin concentrations in relation to body fat, gender, sex hormones and metabolic covariates in Thais. Journal of the Medical Association of Thailand 1999;82:862-867. 26. Piaseu N, Ongphiphadhanakul B, Chailurkit L, Rajatanavin R. Acute suppression of serum intact parathyroid hormone by different calcium preparations in pre- and postmenopausal women. Journal of the Asean Federation of Endocrine Societies 1999;1:50-55. 27. Ditudompo S, Ongphiphadhanakul B, Chanprasertyothin S, Rajatanavin. A De Novo L330S point muataion in thyroid hormone receptor beta gene in a Thai female with resistance to thyroid hormone. Endocrine Journal 1999;46:825-829. 28. Ongphiphadhanakul B, Piaseu N, Sae Tung S, Chailurkit L, Rajatanavin R. Prevention of postmenopausal bone loss by low and conventional doses of calcitriol or conjugated equine estrogen. Maturitas 2000;34:179-184.

29. Ongphiphadhanakul B, Chanprasertyothin S, Payatikul P, Sae Tung S, Piaseu N, Chailurkit L, Chansirikarn S, Puavilai G, Rajatanavin R. Oestrogen-receptor-alpha gene polymorphism affects response in bone mineral density to oestrogen in post-menopausal women. Clinical Endocrinology 2000;52:581-585. 30. Bunnag P, Chanprasertyothin S, Kongsuksai A, Ongphiphadhanakul B, Rajatanavin R, Puavilai G. Correlation between serum insulin and features of metabolic syndrome in Thais. Journal of the Medical Association of Thailand. 2000;83:783-789. 31. Domrongkitchaiporn S, Ongphiphadhanakul B, Stitchantrakul W, Piaseu N, Chansirikarn S, Puavilai G, Rajatanavin R. Risk of calcium oxalate nephrolithiasis after calcium or combined calcium and calcitriol supplementation in postmenopausal women. Osteoporosis International 2000;11:486-492. 32. Changsirikulchai S, Domrongkitchaiporn S, Sirikulchayanonta V, Ongphiphadhanakul B. Kunkitti N, Stitchantrakul W, Radienahamed P. Renal osteodystrophy in Ramathibodi Hospital: histomorphometry and clinical correlation. J Med Assoc Thai 2000;83:1223-1232. 33. Chanprasertyothin S, Ongphiphadhanakul B, Rajatanvin R, Piaseu N, Chailurkit L, Puavilai G. Correlation of apolipoprotien E gene polymorphism to serum lipid concentrations in healthy Thais. Journal of the Medical Association of Thailand. 2000;83:1233-1238. 34. Krittiyawong S, Ongphiphadhanakul B, Chanprasertyothin S, Reutrakul S, Bunnag P, Rajatanavin R, Puavilai G. Diabetes mellitus in young Thai adults. J Med Assoc Thai 2000;83:1283-1288. 35. Chailurkit L, Ongphiphadhanakul B, Piaseu N, Rajatanavin R. Osteoblastic function as assessed by biochemical markers of bone formation in males and females. Journal of the Asean Federation of Endocrine Societies 2000;18:22-27. 36. Domrongkitchaiporn S, Pongsakul C, Stitchantrakul W, Sirikulchayanonta V, Ongphiphadhanakul B, Radinahamed P, Karnsombut P, Kunkitti N. Bone mineral density and histology in distal renal tubular acidosis. Kidney Int 2001;59:10861093. 37. Chailurkit LO, Ongphiphadhanakul B, Piaseu N, Saetung S, Rajatanavin R. Biochemical markers of bone turnover and response of bone mineral density to intervention in early postmenopausal women: an experience in a clinical laboratory. Clinical Chemistry 2001;47:1083-1088. 38. Thamprajamchit S, Ongphiphadhanakul B, Krittiyawong S, Chanprasertyothin S, Bunnag P, Rajatanavin R, Puavilai G. A simple prediction rule and a neural network model to predict pancreatic beta-cell reserve in young adults with diabetes mellitus. Journal of the Medical Association of Thailand 2001;84:332338. 39. Piaseu N, Komindr S, Chailurkit LO, Ongphiphadhanakul B, Chansirikarn S, Rajatanavin R. Differences in bone mineral density and lifestyle factors of postmenopausal women living in Bangkok and other provinces. Journal of the Medical Association of Thailand 2001; 84:772-81. 40. Ongphiphadhanakul B, Chanprasertyothin S, Payattikul P, Saetung S, Piaseu N, Chailurkit L, Chansirikarn S, Puavilai G, Rajatanavin R. Association of a T262C transition in exon 1 of estrogen-receptor-alpha gene with skeletal responsiveness to estrogen in post-menopausal women. Journal of Endocrinological Investigation 2001; 24:749-55. 41. Ongphiphadhanakul B, Chanprasertyothin S, Payattikul P, Saetung S, Piaseu N, Chailurkit L, Rajatanavin R. Association of a G2014A transition in exon 8 of the estrogen-receptor-alpha gene with postmenopausal osteoporosis. Osteoporosis International 2001;12:1015-9. 42. Domrongkitchaiporn S, Ongphiphadhanakul B, Stitchantrakul W, Chansirikarn S, Puavilai G, Rajatanavin R. Risk of calcium oxalate nephrolithiasis in

postmenopausal women supplemented with calcium or combined calcium and estrogen. Maturitas 2002;6;41:149-56. 43. Ongphiphadhanakul B, Thamprajamchit S, Chanprasertyothin S, Chailurkit L, Rajatanavin R. Effect of estrogen replacement on insulin sensitivity, serum lipid and bone resorption marker in hypogonadal males. Maturitas 2002;42:85-9. 44. Ongphiphadhanakul B. Osteoporosis in Thailand. Clinical Calcium 2002;12:1248. 45. Domrongkitchaiporn S, Pongskul C, Sirikulchayanonta V, Stitchantrakul W, Leeprasert V, Ongphiphadhanakul B, Radinahamed P, Rajatanavin R. Bone histology and bone mineral density after correction of acidosis in distal renal tubular acidosis. Kidney International. 2002;62:2160-6. 46. Ongphiphadhanakul B. Genetic polymorphisms of estrogen receptor-α: possible implications for targeted osteoporosis therapy. American Journal of Pharmacogenomics 2003;3:5-9. 47. Ongphiphadhanakul B, Chanprasertyothin S, Payattikul P, Saetung S, Rajatanavin R. The implication of assessing a polymorphism in estrogen receptor alpha gene in the risk assessment of osteoporosis using a screening tool for osteoporosis in Asians. Osteoporosis International 2003;14:863-7. 48. Chailurkit LO, Jongjaroenprasert W, Rungbunnapun S, Ongphiphadhanakul B, Sae-tung S, Rajatanavin R. Effect of alendronate on bone mineral density and bone turnover in Thai postmenopausal osteoporosis. Journal of Bone and Mineral Metabolism 2003;21:421-7. 49. Chailurkit LO, Aunphongpuwanart S, Ongphiphadhanakul B, Jongjaroenprasert W, Sae-tung S, Rajatanavin R. Efficacy of intermittent low dose alendronate in Thai postmenopausal osteoporosis. Endocrine Research 2004;30:29-36. 50. Ongphiphadhanakul B, Chanprasertyothin S, Chailurkit L, Chansirikarn S, Puavilai G, Rajatanavin R. Differential associations of residual estradiol levels with bone mineral density and serum lipids in postmenopausal women with osteoporosis. Maturitas 2004;48:193-6. 51. Ongphipahdhanakul B, Chanprasertyothin S, Saetung S, Rajatanavin R. A specific haplotype in the 3' end of estrogen-receptor alpha gene is associated with low bone mineral density in premenopausal women and increased risk of postmenopausal osteoporosis. Osteoporosis International 2005;16:1233-8. 52. Poomthavorn P, Mahachoklertwattana P, Ongphiphadhaankul B, Preeyasombat C, Rajatanavin R. Exogenous subclinical hyperthyroidism during adolescence: effect on peak bone mass. J Pediatric Endocrinology and Metabolism 2005;18:463-9. 53. Tantiwong P, Puavilai G, Ongphiphadhanakul B, Bunnag P, Ngarmukos C. Capillary blood beta-hydroxybutyrate measurement by reagent strip in diagnosing diabetic ketoacidosis. Clinical Laboratory Science. 2005;18:139-44. 54. Chanprasertyothin S, Piaseu N, Chailurkit L, Rajatanavin R, Ongphiphadhanakul B. Association of circulating leptin with bone mineral density in males and females. Journal of the Medical Association of Thailand 2005;88:655-9. 55. Chaimuangraj S, Thammachoti R, Ongphiphadhanakul B, Thammavit W. Lack of association of VDR polymorphisms with Thai prostate cancer as compared with benign prostate hyperplasia and controls. Asian Pacific Journal of Cancer Prevention 2006; 7: 136-9. 56. Kung AW, Pasion EG, Sofiyan M, Lau EM, Tay BK, Lam KS, Wilawan K, Ongphiphadhanakul B, Thiebaud D.A comparison of teriparatide and calcitonin therapy in postmenopausal Asian women with osteoporosis: a 6-month study. Current Medical Research and Opinion 2006;22:929-37. 57. Chaiyakunapruk N, Laowakul A, Karnchanarat S, Pikulthong N, Ongphiphadhanakul B. Community pharmacy-based implementation and evaluation of an osteoporosis self-assessment tool for Asians.

Journal of the American Pharmaceutical Association (Washington, DC). 2006;4 6: 391-6. 58. Chanprasertyothin S, Saetung S, Payattikul P, Rajatanavin R, Ongphiphadhanakul B. Relationship of body composition and circulatory adiponectin to bone mineral density in young premenopausal women. Journal of the Medical Association of Thailand 2006; 89: 1579-83. 59. Chailurkit LO, Jongjaroenprasert W, Chanprasertyothin S, Ongphiphadhanakul B. Insulin and C-peptide levels, pancreatic beta cell function, and insulin resistance across glucose tolerance status in Thais. Journal of Clinical Laboratory Analysis 2007; 21: 85-90. 60. Poomthavorn P, Ongphiphadhanakul B, Mahachoklertwattana P. Transient neonatal hypoparathyroidism in two siblings unmasking maternal normocalcemic hyperparathyroidism. Transient neonatal hypoparathyroidism in two siblings unmasking maternal normocalcemic hyperparathyroidism. European Journal of Pediatrics 2007 Jun 15; [Epub ahead of print] 61. Keesukphan P, Chanprasertyothin S, Ongphiphadhanakul B, Puavilai G. The development and validation of a diabetes risk score for high-risk Thai adults. Journal of the Medical Association of Thailand 2007; 90: 149-54. 62. Ongphiphadhanakul B. Osteoporosis: the role of genetics and the environment. Forum in Nutrition 2007; 60: 158-67. 63. Dansuntornwong B, Chanprasertyothin S, Jongjaroenprasert W, Ngarmukos C, Bunnag P, Puavilai G, Ongphiphadhanakul B. The relation between parameters from homeostasis model assessment and glycemic control in type 2 diabetes. Journal of the Medical Association of Thailand 2007; 90: 2284-90. 64. Jongjaroenprasert W, Chanprasertyothin S, Kongsuksai A, Bunnag P, Puavilai G, Ongphiphadhanakul B. Association of genetic variations near P2 promoter of the hepatocyte nuclear factor-4alpha gene and insulin secretion index in Thais. Acta Diabetol. 2007;44: 227-32. 65. Saetung S, Ongphiphadhanakul B, Rajatanavin R The relationship of an Asianspecific screening tool for osteoporosis to vertebral deformity and osteoporosis. Journal of Bone and Mineral Metabolism 2008; 26: 47-52. 66. Jongjaroenprasert W, Chanprasertyotin S, Butadej S, Nakasatien S, Charatcharoenwitthaya N, Himathongkam T, Ongphiphadhanakul B. Association of genetic variants in GABRA3 gene and thyrotoxic hypokalaemic periodic paralysis in Thai population. Clinical Endocrinology 2008; 68: 646-51. 67. Chaikledkaew U, Pongchareonsuk P, Chaiyakunapruk N, Ongphiphadhanakul B. Factors affecting health-care costs and hospitalizations among diabetic patients in Thai public hospitals. Value in Health. 2008;11 Suppl 1:S69-74. 68. Chirakup S, Chaiyakunapruk N, Chaikledkeaw U, Pongcharoensuk P, Ongphiphadhanakul B, Roze S, Valentine WJ, Palmer AJ. Cost-effectiveness analysis of thiazolidinediones in uncontrolled type 2 diabetic patients receiving sulfonylureas and metformin in Thailand. Value in Health. 2008;11 Suppl 1:S4351. 69. Chailurkit LO, Chanprasertyothin S, Jongjaroenprasert W, Ongphiphadhanakul B. Differences in insulin sensitivity, pancreatic beta cell function and circulating adiponectin across glucose tolerance status in Thai obese and non-obese women. Endocrine. 2008;33:84-9. 70. Dansuntornwong B, Chanprasertyothin S, Jongjaroenprasert W, Ngarmukos C, Bunnag P, Puavilai G, Ongphiphadhanakul B. The relation between parameters from homeostasis model assessment and glycemic control in type 2 diabetes. Journal of the Medical Association of Thailand. 2007;90:2284-90. 71. Saetung S, Ongphiphadhanakul B, Rajatanavin R. The relationship of an Asianspecific screening tool for osteoporosis to vertebral deformity and osteoporosis. Journal of Bone and Mineral Metabolism. 2008;26:47-52.

72. Chailurkit LO, Chanprasertyothin S, Rajatanavin R, Ongphiphadhanakul B. Reduced attenuation of bone resorption after oral glucose in type 2 diabetes. Clinical Endocrinology. 2008;68:858-62. 73. Rungtanapirom S, Ongphiphadhanakul B, Kiatbamrungpunt T, Bhakdikul J, Archavanuntakun S, Taerakul C, Pongsanguansin J, Charoenloet V, Tansanguan K. Comparative study of direct-measured and calculated LDL in clinical use. Journal of the Medical Association of Thailand. 2008;91:989-94. 74. Ngarmukos C, Chanprasertyothin S, Puavilai G, Ongphiphadhanakul B. The preservation of insulin sensitivity in obese women without diabetes. Journal of the Medical Association of Thailand. 2008;91:659-64.