CURRICULUM VITAE

CURRICULUM VITAE Yoshitaka Hamashima ... “Dual Catalysis with Copper and Rhenium for ... “Synthesis of Theaflavin via Biomimetic Oxidative Coupling Re...

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CURRICULUM VITAE

Yoshitaka Hamashima, Ph. D.

Current Address: School of Pharmaceutical Sciences University of Shizuoka 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan Phone: 81-54-264-5672 e-mail: [email protected] URL: http://w3pharm.u-shizuoka-ken.ac.jp/lsocus/index.html

Personal Information: Date of Birth:

June 9, 1974

Citizenship:

Japanese

Current Status: Full Professor of Organic Chemistry at University of Shizuoka

Education and Research Positions: 4/1999- 3/2001

PhD course at the University of Tokyo (Prof. M. Shibasaki)

4/2001

Assistant professor at Tohoku University (Prof. M. Sodeoka’s group)

9/2003

Received a Ph.D. degree from the University of Tokyo

5/2005

Lecturer at Tohoku University

4/2006-3/2008

Researcher at RIKEN (Prof. M. Sodeoka’s group)

4/2008

Senior Researcher at RIKEN

5/2010

Associate Professor at University of Shizuoka (Prof. Kan’s group)

4/2013

Full Professor at University of Shizuoka

Ph.D Thesis: Development of Lewis acid-Lewis base bifunctional catalysts and their application to catalytic asymmetric cyanosilylation of aldehydes and ketones (Under the direction of Prof. Masakatsu Shibasaki)

Awards: - Meiji Seika Award in Synthetic Organic Chemistry, Japan (2003) - Thieme Journal Award (2006) - The PSJ Award for Young Scientists (2006)

Research Interests: - Design and synthesis of metal complexes and their applications to catalytic reactions - Synthetic studies of fluorinated compounds and halogenation reactions - Synthetic studies of biologically active natural and unnatural compounds Publications: a) Peer-reviewed papers 69)

“Practical Total Syntheses of Acromelic Acids A and B”

M. Inai, H. Ouchi, A. Asahina, T. Asakawa, Y. Hamashima, and T. Kan Chem. Pharm. Bull. 2016, in press. 68)

“Synthesis of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect

and deactivate phenol” T. Kan, T. Asakawa, Y. Kawabe, A. Yoshida, Y. Aihara, T. Manabe, Y. Hirose, A. Sakurada, M. Inai, Y. Hamashima, T. Furuta, and T. Wakimoto J. Antibiot. 2016, in press. 67)

“Highly Enantioselective Bromocyclization of Allylic Amides with a P/P=O Double-site Lewis

Base Catalyst” Y. Kawato, H. Ono, A. Kubota, Y. Nagao, N. Morita, H. Egami, and Y. Hamashima Chem. Eur. J. 2016, 22, 2127-2133. 66)

“Benzylic C–H Trifluoromethylation of Phenol Derivatives”

H. Egami, T. Ide, Y. Kawato, Y. Hamashima Chem. Commun., 2015, 51, 16675-16678. 65)

“Asymmetric Fluorolactonization with a Bifunctional Hydroxyl Carboxylate Catalyst”

H. Egami, J. Asada, K. Sato, Y. Kawato, Y. Hamashima J. Am. Chem. Soc., 2015, 137, 10132-10135. 64)

“Stereocontrolled Total Syntheses of Optically Active Furofuran Lignans”

M. Inai, R. Ishikawa, N. Yoshida, N. Shirakawa, Y. Akao, Y. Kawabe, T. Asakawa, M. Egi, Y. Hamashima, T. Kan Synthesis, 2015, 47, 3513-3521. 63)

“2-[(Neopentyl glycolate)boryl]phenyl Triflates and Halides for Fluoride Ion-Mediated

Generation of Functionalized Benzynes” T. Ikawa, R. Yamamoto, A. Takagi, T. Ito, K. Shimizu, M. Goto, Y. Hamashima, S. Akai

Adv. Synth. Catal., 2015, 357, 2287-2300. 62)

“Concise Synthesis of Binaphthol-derived Chiral Dicarboxylic Acids”

H. Egami, K. Sato, J. Asada, Y. Kawato, Y. Hamashima Tetrahedron, 2015, 71, 6384-6388. 61)

“Advanced

dress-up

chiral

columns:

New

removable

chiral

stationary

phases

for

enantioseparation of chiral carboxylic acids” K. Todoroki, Y. Ishii, T. Ide, J.- Z. Min, K. Inoue, X. Huang, W. Zhang, Y. Hamashima, T. Toyo’oka Analytica Chimica Acta, 2015, 882, 101-111. 60)

“Enantioselective Bromocyclization of Allylic Amides Catalyzed by BINAP Derivatives”

Y. Kawato, A. Kubota, H. Ono, H. Egami, Y. Hamashima Org. Lett., 2015, 17, 1244-1247. 59)

“Development of a highly efficient single-mode microwave applicator with a resonant cavity and

its application to continuous flow synthesese” S. Yokozawa, N. Ohneda, K. Muramatsu, T. Okaoto, H. Odajima, T. Ikawa, J. Sugiyama, M. Fujita, T. Sawairi, H. Egami, Y. Hamashima, M. Egi, S. Akai RSC Adv., 2015, 5, 10204-10210. 58)

“Total Synthesis of (+)-Sesamin and (+)-Sesaminol”

R. Ishikawa, N. Yoshida, Y. Akao, M. Inai, T. Asakawa, Y. Hamashima, T. Kan Chem. Lett. 2014, 43, 1572-1574. 57)

“Dual Catalysis with Copper and Rhenium for Trifluoromethylation of Propargylic Alcohols:

Efficient Synthesis of α-Trifluroromethylated Enones” H. Egami, T. Ide, M. Fujii, T. Tojo, Y. Hamashima, M. Sodeoka Chem. Eur. J. 2014, 20, 12061-12065. 56)

“Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and

biotin-labeled probes” K. Ikeuchi, R. Fujii, S. Sugiyama, T. Asakawa, M. Inai, Y. Hamashima, J.-H. Choi, T. Suzuki, H. Kawagishi, T. Kan Org. Biomol. Chem., 2014, 2014, 12, 3813-3815. 55)

“Practical Total Syntheses of Acromelic Acids A and B”

H. Ouchi, A. Asahina, T. Asakawa, M. Inai, Y. Hamashima, T. Kan Org. Lett., 2014, 16, 1980-1983. 54)

“Stereocontrolled Total Synthesis of Hedyotol A”

Y. Kawabe, R. Ishikawa, Y. Akao, A. Yoshida, M. Inai, T. Asakawa, Y. Hamashima, T. Kan Org. Lett., 2014, 16, 1976-1979. 53)

“Practical Synthesis of Kainoids: A New Chemical Probe Precursor and a Fluorescent Probe”

S. Sasaki, H. Suzuki, H. Ouchi, T. Asakawa, M. Inai, R. Sakai, K. Shimamoto, Y. Hamashima, T. Kan Org. Lett., 2014, 16, 564-567. 52)

“Synthetic Studies of Fisetin, Myricetin and Nobiletin Analogs and Related Probe Molecules”

A. Hiza, Y. Tsukaguchi, T. Ogawa, M. Inai, T. Asakawa, Y. Hamashima, T. Kan HETEROCYCLES, 2014, 88, 1371-1396. 51)

“Stereocontrolled total synthesis of sphingofungin E” K. Ikeuchi, M. Hayashi, T. Yamamoto, M. Inai, T. Asakawa, Y. Hamashima, T. Kan Eur. J. Org. Chem. 2013, 30, 6789-6792.

50)

“Chemoselective

Hydrogenation

Reaction

of

Unsaturated

Bonds

in

the

Presence

of

o-Nitrobenzenesulfonyl Group” A. Kawanishi, C. Miyamoto, Y. Yabe, M. Inai, T. Asakawa, Y. Hamashima, H. Sajiki, T. Kan Org. Lett., 2013, 15, 1306-1309. 49)

“Synthesis of Theaflavin via Biomimetic Oxidative Coupling Reaction”

Y. Kawabe, Y. Aihara, Y. Hirose, A. Sakurada, A. Yoshida, M. Inai, T. Asakawa, Y. Hamashima, T. Kan Synlett, 2013, 479-482. 48)

“Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors:

Reducing cytotoxicity by structural simplification” S. Fujishiro, K. Dodo, E. Iwasa, Y. Sohtome, Y. Hamashima, A. Ito, M. Yoshida, M. Sodeoka Bioorg. Med. Chem. Lett. 2013, 23, 733-736. 47)

“Catalytic Desymmetrization of Cyclohexadienes via Asymmetric Bromolactonization”

K. Ikeuchi, K. Ido, S. Yoshimura, T. Asakawa, M. Inai, Y. Hamashima, T. Kan Org. Lett. 2012, 14, 6016-6019. 46)

“Stereocontrolled Total Synthesis of (+)- UCS1025A”

K. Uchida, T. Ogawa, Y. Yasuda, H. Mimura, T. Fujimoto, T. Fukuyama, T. Wakimoto, T. Asakawa, Y. Hamashima, T. Kan, Angew. Chem., Int. Ed. 2012, 51, 12850-12853. 45)

“Total Synthesis of (-)-Lemonomycin”

A. Yoshida, M. Akaiwa, T. Asakawa, Y. Hamashima, S. Yokoshima, T. Fukuyama, T. Kan Chem. Eur. J. 2012, 18, 11192-11195. 44)

“A Short-step Asymmetric Synthesis of Dehydrodiconifery Alcohol (DCA) via C-H Insertion

Reaction” S. Matsumoto, T. Asakawa, Y. Hamashima, T. Kan Synlett 2012, 1082-1084. 43) “Copper-Catalyzed Trifluoromethylation of Allylsilanes” R. Shimizu, H. Egami, Y. Hamashima, M. Sodeoka Angew. Chem., Int. Ed. 2012, 51, 4577-4580. 42) “Catalytic Asymmetric Mono-fluorination of α-Keto Ester: Synthesis of Optically Active α-Hydroxy-β-fluoro Esters and α-Amino-β-fluoro Esters” S. Suzuki, Y. Kitamura, S. Lectard, Y. Hamashima, M. Sodeoka Angew. Chem., Int. Ed. 2012, 51, 4581-4585.

41) “Synthesis and Biological Activities of Chaetocin and its Derivatives” M. Sodeoka, K. Dodo, Y. Teng, K. Iuchi, Y. Hamashima, E. Iwasa, S. Fujishiro Pure Appl. Chem. 2012, 84, 1369-1378. 40) “Catch & release of alkyne-tagged molecules in water by polymer-supported cobalt complex” H. Egami, S. Kamisuki, K. Dodo, M. Asanuma, Y. Hamashima, M. Sodeoka Org. Biomol. Chem. 2011, 9, 7667-7670. 39) “Total syntheses of chaetocin and ent-chaetocin” E. Iwasa, S. Fujishiro, Y. Hamashima, M. Sodeoka Tetrahedron 2011, 67, 6587-6599. 38) “Catalytic Asymmetric α-Chlorination of 3-Acyl-oxazolidin-2-one with a Trinary Catalytic System” Y. Hamashima, T. Nagi, R. Shimizu, T. Tsuchimoto, M. Sodeoka Eur. J. Org. Chem. 2011, 20-21, 3675-3678. 37) “Scope and Mechanism of Tandem Aza-Michael Reaction/Enantioselective Protonation Using a Pd-µ-Hydroxo Complex under Mild Conditions Buffered with Amine Salts” Y. Hamashima, S. Suzuki, T. Tamura, H. Somei, M. Sodeoka Chem. Asian J. 2011, 6, 658-668. 36) “Direct C2-trifluoromethylation of indole derivatives catalyzed by copper acetate” R. Shimizu, H. Egami, T. Nagi, J. Chae, Y. Hamashima, M. Sodeoka Tetrahedron Lett. 2010, 51, 5947-5949. 35) “Unnatural

enantiomer

of

chaetocin

shows

strong

apoptosis-inducing

activity

through

caspase-8/caspase-3 activation” Y. Teng, K. Iuchi, E. Iwasa, S. Fujishiro, K. Dodo, Y. Hamashima, M. Sodeoka Bioorg. Med. Chem. Lett. 2010, 20, 5085-5088. 34) “Diastereo- and Enantioselective Conjugate Addition of α-Ketoesters to Nitroalkenes Catalyzed by Chiral Ni(OAc)2 Complex under Mild Conditions” A. Nakamura, S. Lectard, D. Hashizume, Y. Hamashima, M. Sodeoka J. Am. Chem. Soc. 2010, 132, 4036-4037. 33) “Total Synthesis of (+)-Chaetocin and its Analogs: Their Histone Methyltransferase G9a Inhibitory Activity” E. Iwasa, Y. Hamashima, S. Fujishiro, E. Higuchi, A. Ito, M. Yoshida, M. Sodeoka J. Am. Chem. Soc. 2010, 132, 4078-4079. 32) “Asymmetric conjugate addition of α-keto esters to nitroolefins catalyzed by chiral CuII hydroxo complexes” A. Nakamura, S. Lectard, R. Shimizu, Y. Hamahsima, M. Sodeoka Tetrahedron: Asymmetry 2010, 21, 1682-1687. 31) “Enantioselective Protonation in the Aza-Michael Reaction Using a Combination of Chiral Pd-µ-Hydroxo Complex with an Amine Salt” Y. Hamashima, T. Tamura, S. Suzuki, M. Sodeoka

Synlett 2009, 1631-1634. 30)

“Mechanistic

Studies

on

the

Catalytic

Asymmetric

Mannich-Type

Reaction

with

Dihydroisoquinolines and Development of Oxidative Mannich-type Reactions Starting from Tetrahydroisoquinolines” C. Dubs, Y. Hamashima, N. Sasamoto, T. M. Seidel, S. Suzuki, D. Hashizume, M. Sodeoka J. Org. Chem. 2008, 73, 5859-5871. 29) “PdII-catalyzed Asymmetric Addition Reactions of 1,3-Dicarbonyl Compounds: Mannich-type Reactions with N-Boc Imines and Three-component Aminomethylation” Y. Hamashima, N. Sasamoto, N. Umebayashi, M. Sodeoka Chem. Asian J. 2008, 3, 1143-1155. 28) “Catalytic Enantioselective Aldol-type Reaction of β-Ketoesters with Acetals” N. Umebayashi, Y. Hamashima, D. Hashizume, M. Sodeoka Angew. Chem., Int. Ed. 2008, 47, 4196-4199. 27) “Catalytic

asymmetric

conjugate

reduction

with

ethanol:

A

more

reactive

system

Pd(II)-iPr-DUPHOS complex with molecular sieves 4A” D. Monguchi, C. Beemelmanns, D. Hashizume, Y. Hamashima, M. Sodeoka J. Organomet. Chem. 2008, 693, 867-873. 26) “Synthesis of optically active heterocyclic compounds using Pd-catalyzed asymmetric reactions as a key step” M. Sodeoka, Y. Hamashima Pure Appl. Chem. 2008, 80, 763-776. 25) “Asymmetric Fluorination of α-Aryl Acetic Acid Derivatives with the Catalytic System NiCl2-Binap/R3SiOTf /2,6-Lutidine” T. Suzuki, Y. Hamashima, M. Sodeoka Angew. Chem., Int. Ed. 2007, 46, 5435-5439. 24) “Pd(II)-Catalyzed Asymmetric Fluorination of α-Aryl-α-cyanophosphonates with the Aid of 2,6-Lutidine” K. Moriya, Y. Hamashima, M. Sodeoka Synlett 2007, 1139-1142. 23) “Enantioselective Fluorination of tert-Butoxycarbonyl Lactones and Lactams Catalyzed by Chiral Pd(II)-Bisphosphine Complexes” T. Suzuki, T. Goto, Y. Hamashima, M. Sodeoka J. Org. Chem. 2007, 72, 246-250. 22) “Catalytic Asymmetric Aldol Reactions of Enolizable Carbon Pronucleophiles with Formaldehyde and Ethyl Glyoxylate” I. Fukuchi, Y. Hamashima, M. Sodeoka Adv. Synth. Catal. 2007, 349, 509-512. 21) “A New Entry to Pd-H Chemistry: Catalytic Asymmetric Conjugate Reduction of Enones with EtOH

and a Highly Enantioselective Synthesis of Warfarin” Y. Tsuchiya, Y. Hamashima, M. Sodeoka Org. Lett. 2006, 8, 4851-4854. 20) “Pd(II)-Catalyzed Asymmetric Addition of Malonates to Dihydroisoquinolines” N. Sasamoto, C. Dubs, Y. Hamashima, M. Sodeoka J. Am. Chem. Soc. 2006, 128, 14010-14011. 19) “Highly enantioselective fluorination reactions of β-ketoesters and β-ketophosphonates catalyzed by chiral palladium complexes” Y. Hamashima, T. Suzuki, H. Takano, Y. Shimura, Y. Tsuchiya, K. Moriya, T. Goto, M. Sodeoka Tetrahedron 2006, 62, 7168-7179. 18) “Acid-base catalysis using chiral palladium complexes” M. Sodeoka, Y. Hamashima, Pure Appl. Chem. 2006, 78, 477-494. 17) “Catalytic Enantioselective Michael Reaction of 1,3-Dicarbonyl Compounds via Formation of Chiral Palladium Enolate” Y. Hamashima, D. Hotta, N. Umebayashi, Y. Tsuchiya, T. Suzuki, M. Sodeoka Adv. Synth. Catal. 2005, 347, 1576-1586. 16) “Catalytic Enantioselective Fluorination of Oxindoles” Y. Hamashima, T. Suzuki, H. Takano, Y. Shimura, M. Sodeoka J. Am. Chem. Soc. 2005, 127, 10164-10165. 15) “An efficient catalytic enantioselective fluorination of β-ketophosphonates using chiral palladium complexes” Y. Hamashima, T. Suzuki, Y. Shimura, T. Shimizu, N. Umebayashi, T. Tamura, N. Sasamoto, M. Sodeoka Tetrahedron Lett. 2005, 46, 1447-1450. 14) “Catalytic Asymmetric Addition of β-Ketoesters to Various Imines by Using Chiral Palladium Complexes” Y. Hamashima, N. Sasamoto, D. Hotta, H. Somei, N. Umebayashi, M. Sodeoka Angew. Chem., Int. Ed. 2005, 44, 1525-1529. 13) “Development of Catalytic Enantioselective Reactions via Palladium Enolates as Key Intermediates” M. Sodeoka, Y. Hamashima Bull. Chem. Soc. Jpn. 2005, 78, 941-956. 12) “Amine-Salt-Controlled, Catalytic Asymmetric Conjugate Addition of Various Amines and Asymmetric Protonation” Y. Hamashima, H. Somei, Y, Shimura, T. Tamura, M. Sodeoka Org. Lett. 2004, 6, 1861-1864. 11) “Immobilization and Reuse of Pd Complexes in Ionic Liquid: Efficient Catalytic Asymmetric Fluorination and Michael Reactions with β-Ketoesters”

Y. Hamashima, H. Takano, D. Hotta, M. Sodeoka Org. Lett. 2003, 5, 3225-3228. 10) “An Efficient Enantioselective Fluorination of Various β-Ketoesters Catalyzed by Chiral

Palladium

Complexes” Y. Hamashima, K. Yagi, H. Takano, L. Tamás, M. Sodeoka J. Am. Chem. Soc. 2002, 124, 14530-14531. 9) “Direct Generation of Nucleophilic Chiral Palladium Enolate from 1,3-Dicarbonyl Compounds: Catalytic Enantioselective Michael Reaction with Enones” Y. Hamashima, D. Hotta, M. Sodeoka J. Am. Chem. Soc. 2002, 124, 11240-11241. 8) “Switching Enantiofacial Selectivities Using One Chiral Source: Catalytic Enantioselective Synthesis of the Key Intermediate for (20S)-Camptothecin Family by (S)-Selective Cyanosilylation of Ketones” K. Yabu, S. Masumoto, S. Yamasaki, Y. Hamashima, M. Kanai, W. Du, D. P. Curran, M. Shibasaki J. Am. Chem. Soc. 2001, 123, 9908-9909. 7) “Highly enantioselective cyanosilylation of aldehydes catalyzed by a Lewis acid-Lewis base bifunctional catalyst” Y. Hamashima, D. Sawada, H. Nogami, M. Kanai, M. Shibasaki Tetrahedron 2001, 57, 805-814. 6) “Catalytic enantioselective cyanosilylation of ketones: improvement of enantioselectivity and catalyst turn-over by ligand tuning” Y. Hamashima, M. Kanai, M. Shibasaki Tetrahedron Lett. 2001, 42, 691-694. 5) “Catalytic Enantioselective Cyanosilylation of Ketones” Y. Hamashima, M. Kanai, M. Shibasaki, J. Am. Chem. Soc. 2000, 122, 7412-7413. 4) “Design of a new bifunctional asymmetric catalyst from carbohydrates: application to catalytic asymmetric cyanosilylation of aldehydes and acetophenone” M. Kanai, Y. Hamashima, M. Shibasaki Tetrahedron Lett. 2000, 41, 2405-2409. 3) “A Catalytic Asymmetric Strecker-Type Reaction Promoted by Lewis Acid-Lewis Base Bifunctional Catalyst” M. Takamura, Y. Hamashima, H. Usuda, M. Kanai, M. Shibasaki Chem. Pharm. Bull. 2000, 48, 1586-1592. 2) “A Catalytic Asymmetric Strecker-Type Reaction: Interesting Reactivity Difference between TMSCN and HCN” M. Takamura, Y. Hamashima, H. Usuda, M. Kanai, M. Shibasaki Angew. Chem., Int. Ed. 2000, 39, 1650-1652. 1) “A New Bifunctional Asymmetric Catalysis: An Efficient Catalytic Asymmetric Cyanosilylation

of

Aldehydes” Y. Hamashima, D. Sawada, M. Kanai, M. Shibasaki J. Am. Chem. Soc. 1999, 121, 2641-2642. b)

Reviews

9) “Chemical synthesis of tea polyphenols and related compounds” T. Asakawa, Y. Hamashima, T. Kan Curr. Pharm. Des, 2013, 19, 6207-6217. 8) “Epipolythiodiketopiperazine Alkaloids: Total Syntheses and Biological Activities” E. Iwasa, Y. Hamashima, M. Sodeoka Israel J. Chem. 2011, 51, 420-433. 7) “Recent Advances in Catalytic Enantioselective Fluorination Reactions” S. Lectard, Y. Hamashima, M. Sodeoka Adv. Synth. & Catal. 2010, 352, 2708-2732. 6) “Development of Novel Catalytic Asymmetric Reactions Using Cationic Group-10 Metal Complexes: With a Special Focus on Reactions in which Palladium Enolates Plays a Key Role” Y. Hamashima, M. Sodeoka TCI MAIL, 2010, 140, 2-16. 5)

“Chiral Pd aqua complex-catalyzed asymmetric C-C bond-forming reactions: a Brønsted acid-base cooperative system” M. Sodeoka, Y. Hamashima Chem. Commun. 2009, 5787-5798.

4) “Catalytic Enantioselective α-Fluorination of Carbonyl Compounds Using Chiral Transition Metal Complexes” Y. Hamashima, M. Sodeoka J. Synth. Org. Chem., Jpn. 2007, 65, 1099-1107. 3)

“Acid-Base Catalysis of Chiral Palladium Complexs: Development of Novel Asymmetric Reactions and Their Application to Synthesis of Drug Candidates” Y. Hamashima Chem. Pharm. Bull. 2006, 54, 1351-1364.

2)

“Enantioselective Fluorination Reactions Catalyzed by Chiral Palladium Complexes” Y. Hamashima, M. Sodeoka Synlett 2006, 1467-1478.

1)

“Development of Catalytic Asymmetric Reactions via Chiral Palladium Enolates” Y. Hamashima, M. Sodeoka Chem. Rec. 2004, 4, 231-242.

Invited Lectures (international conferences):

6)

“Asymmetric halofunctionalization of olefins with novel bifunctional organocatalysts” Y. Hamashima The International Chemical Congress of Pacific Basin Societies 2015(Hawaii)2015. 12. 17.

5)

“Continuous flow synthesis using a new type of microwave applicator” Y. Hamashima The United Kingdom Automated Synthesis Forum(Nottingham, UK)2015. 11. 12.

4)

“Asymmetric bromolactonization and its application to natural product synthesis” Y. Hamashima Japan-USA Organocatalytic Symposium (Hawaii) 2012. 12. 15-18.

3)

“Acid-base Catalysis with Transition Metal Complexes in Asymmetric C-C Bond-forming Reactions” Y. Hamashima BIT’s 1st Annual World Congress of Catalytic Asymmetric Synthesis 2010 (Beijing) 2010. 5. 19-21.

2)

“Acid-base Catalysis with Transition Metal Complexes in Asymmetric C-C Bond-forming Reactions” Y. Hamashima 5th Spanish-Portuguese-Japanese Organic Chemistry Symposium (Osaka University) 2009. 11. 6-8.

1)

“Enantioselective Catalysis Based on Transition Metal Enolate Chemistry” Y. Hamashima Gordon Research Conference-Stereochemistry (Newport, RI, USA) 2008. 7. 30.

Patents: 1)

Method for purification of proteins using cobalt-carbonyl complexes immobilized on solid phases, and ligand-cobalt-carbonyl complex conjugates and kits therefor. M. Sodeoka, K. Dodo, Y. Hamashima, H. Egami, Jpn. Kokai Tokkyo Koho (2011), JP 2011241155 A 20111201.

2)

Chemical synthesis method of functional polyphenol derivatives T. Kan, Y. Hamashima, T. Asakawa, D. Kawamura, Jpn. Kokai Tokkyo Koho (2013), JP 2013151488 A 20130808.

3)

Process for producing optically active β-amino acid. M. Sodeoka, Y. Hamashima, Jpn. Kokai Tokkyo Koho (2010) JP 4446465.

4)

Process for producing optically active β-amino acid. M. Sodeoka, Y. Hamashima, PTC Int. Appl. (2005) WO 2005-016866.

5)

Method for preparation of optically active fluoro ketone compounds. M. Sodeoka, Y. Hamashima, Jpn. Kokai Tokkyo Koho (2004) JP 2004-010555.

6)

Synthesis of chiral ligands as asymmetric catalysts in addition reaction to ketones. M. Shibasaki, M. Kanai, Y. Hamashima, PTC Int. Appl. (2002) WO 2002000668.

7)

Method for preparation of chiral cyano silyl compounds using asymmetric synthesis catalyst

composition M. Shibasaki, H. Nogami, Y. Hamashima, M. Kanai, Jpn. Kokai Tokkyo Koho (2001) JP 2001-348392. 8)

Preparation of optically active 3,3’-bis(phosphinoylalkyl)-1,1’-bi-2-naphthols or their metal coordination complexes and method for preparation of optically active cyanohydrin compounds using the same as catalysts M. Shibasaki, M. Kanai, Y. Hamashima, Jpn. Kokai Tokkyo Koho (2000) JP 2000-191677.

Books: 3)

“Asymmetric cross-dehydrogenative-coupling reactions” Y. Hamashima, M. Sodeoka

RSC Green Chemistry Series, 26, 133-152 (2015) 2)

“Carbon-Carbon Bond-Forming Reactions via Transmetallation Using Silyl Enol Ethers” Y. Hamashima, M. Sodeoka In Comprehensive Chirality (E. M. Carreira, H. Yamamoto et al. Eds.: Elsevier), Vol. 4, 210-213 (2012).

1)

“Michael Addition Reactions” Y. Hamashima, M. Sodeoka In Handbook of C-H Transformations (G. Dyker, Ed.; Wiley-VHC), Vol. 2, 347-359 (2005).