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CURRICULUM VITAE Page 2 • Title: “Occurrence and diversity of integrons in clinical isolates of Enterobacteriaceae from hospitals in Malaysia” S...

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CURRICULUM VITAE Name: Title: Designation: Academic Qualifications:

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Chew Choy Hoong Dr. Assistant Professor BSc (Hons) Applied Science (USM), MSc. (Biology-Biotechnology) (USM), Ph.D (Molecular Biology) (USM) [email protected] Department of Biomedical Science Faculty of Science, University Tunku Abdul Rahman Kampar, 31900, Perak +605-4688888 4426

WORK EXPERIENCE • • •



Medical Laboratory Scientist, Gribbles Pathology Sdn Bhd (1998-2001) Research Fellow (National Science Fellowship. Awarded by Ministry of Science, Technology and Innovation, Malaysia), Universiti Sains Malaysia (2002-2007) Part-Time Lecturer, AIMST University (July-Sept 2005) Assistant Professor, Universiti Tunku Abdul Rahman (2007-current)

PROFESSIONAL BODIES • International Cytokine Society, United States of America. March 2013-2014. • Invited member of FacultyRow, United States of America. August 2013-current

RESEARCH GRANTS External Funding: •

Title: “Elucidation of the effects of lauric acid on key atherogenic mediators and their cell signaling cascades in human monocytic THP-1 cells” Sponsporship: Fundamental Research Grant Scheme (FRGS) (Ministry of Higher Education) Duration/Role: Dec 2013-Nov 2015 (Principal Investigator)



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Title: “Elucidation of the Role of Alpha- and Gamma-synuclein in the Brain-adipose Axis: A Common Link Between Obesity and Parkinson's Disease” Sponsporship: Fundamental Research Grant Scheme (FRGS) (Ministry of Higher Education) Duration/Role: July 2013-June 2015 (Co-Investigator)



Title: “Molecular regulation of ghrelin by pro-inflammatory cytokines in human pancreatic cell lines: a study towards the molecular mechanisms of acute pancreatitis” Sponsporship: Fundamental Research Grant Scheme (FRGS) (Ministry of Higher Education) Duration/Role: July 2010-Oct 2012 (Completed) (Principal Investigator)

“Molecular regulation of farnesoid X receptor (FXR) and its target genes expression by novel cytokines in human umbilical vein endothelial cells, HUVEC” Sponsporship: Science and Technology Research Grant (Malaysia Toray Science Foundation) Duration/Role: Jan 2014-Dec 2014 (Co-Investigator)

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CURRICULUM VITAE •

Title: “Occurrence and diversity of integrons in clinical isolates of Enterobacteriaceae from hospitals in Malaysia” Sponsporship: Science and Technology Research Grant (Malaysia Toray Science Foundation) Duration/Role: Dec 2009-Dec 2011 (Completed) (Co-Investigator)



Title: “Phylogenetic Diversity of Nitrogen Fixation Genes in Microbial Community of Diverse Malaysian Soil Environment” Sponsporship: Science and Technology Research Grant (Malaysia Toray Science Foundation) Duration/Role: Dec 2008-Dec 2010 (Completed) (Co-Investigator)



Title: “Improving Omega 9 (Oleic Acid) Yield in Sunflower using Molecular Biology” Sponsporship: Great Marge Sdn Bhd Duration/Role: July 2009-June 2010 (Completed) (Principal Investigator)



Title: “Identification of the molecular mechanisms of intracellular TNF-alpha signalling pathways underlying the regulation of peroxisome proliferator receptor alpha (PPARalpha) during inflammation.” Sponsporship: E-ScienceFund (Ministry of Science, Technology and Innovation) Duration/Role: Oct 2007-March 2010 (Completed) (Principal Investigator)



Title: “Molecular mechanisms of the development of acute phase response: The regulation of PPARalpha in human liver cells by lipopolysaccahride (LPS) and cytokines)” Sponsporship: Fundamental Research Grant Scheme (FRGS) (MOHE) Duration/Role: 2003-2005 (Completed) (Co-Investigator)

Internal Funding: •

Title: “The regulation of farnesoid X receptor (FXR) expression by pro-inflammatory cytokines in human umbilical vein endothelial cells, HUVEC and murine macrophage cell line, J774 cell line” Sponsporship: UTAR Research Fund (UTARRF) Duration/Role: July 2013-June 2014 (Principal Investigator)



Title: “Investigation on the effects of Cocos nucifera milk compounds on lipid activated nuclear receptors expression in human hepatocarcinoma cells: A nutrigenomics study towards the molecular mechanisms of lipoprotein metabolism” Sponsporship: UTAR Research Fund (UTARRF) Duration/Role: Jun 2012-November 2013 (Completed) (Principal Investigator)



Title: “Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus (MRSA) in Perak hospitals” Sponsporship: UTAR Research Fund (UTARRF) Duration/Role: Feb 2012-June 2013 (Completed) (Co-Investigator)



Title: “Phylogeny and characterisation of novel beta-lactamase homologous genes from bacterial isolates of various ready-to-eat vegetables” Sponsporship: UTAR Research Fund (UTARRF) Duration/Role: Jan 2010-Dec 2011 (Completed) (Co-Investigator)



Title: “Study on the prevalence and dissemination of integrons in multidrug resistant clinical isolates of gram negative bacteria from hospitals in Malaysia” Sponsporship: UTAR Research Fund (UTARRF) Duration/Role: July 2010-June 2011 (Completed) (Principal Investigator)

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CURRICULUM VITAE •

Title: “Molecular characterisation of 5’-untranslated region of human peroxisome proliferator receptor alpha (PPARalpha)” Sponsporship: USM Short Term Grant (USM) Duration/Role: 2001-2003 (Completed) (Co-Investigator)

LIST OF PUBLICATIONS Peer Reviewed Research Articles •

Chew CH, Samian R, Najimudin N, Tengku-Muhammad TS (2003). Molecular characterisation of six alternatively spliced variants and a novel promoter in human peroxisome proliferator-activated receptor alpha (PPARα). Biochemical and Biophysical Research Communications 305, 235-243. (ISI Thompson cited)



Chew CH, Chew GS, Najimudin N, Tengku-Muhammad TS (2007). Interleukin-6 inhibits human peroxisome proliferator activated receptor alpha gene expression via CCAAT/enhancer-binding proteins in hepatocytes. International Journal of Biochemistry & Cell Biology. 39, 1975–1986. (ISI Thompson cited)



Ng DL, Tie SW, Ong PC, Lim WS, Tengku-Muhammad TS, Choo QC and Chew CH (2011). Rapamycin pre-treatment abrogates Tumour Necrosis Factor-α (TNF-α) down-regulatory effects on LXR-α and PXR mRNA expression via inhibition of c-Jun N-terminal kinase 1 (JNK1) activation in HepG2 cells. Electronic Journal of Biotechnology Vol. 14 No. 3, Issue of May 15. (ISI Thompson cited)



Yu YE and Chew CH (2012). Down-regulation in the mRNA expression of nuclear hormone receptor Liver-X-Receptor alpha (LXR-α) by TNF-α is abolished by the antioxidant kaempferol, but not ascorbic acid, in human hepatocarcinoma HepG2 cells. Asian Biomedicine Vol. 6 No. 4 August 2012; 585 - 589. (ISI Thompson cited)



Lao KM, Lim WS, Ng DL, Tengku-Muhammad TS, Choo QC and Chew CH (2013). Molecular Regulation of Ghrelin Expression by Pro-Inflammatory Cytokines TNF-α and IL-6 In Rat Pancreatic AR42J Cell Line. Journal of Biology and Life Science Vol. 4, No. 1.



Lim WS, Ng DL, Kor SB, Wong HK, Tengku-Muhammad TS, Choo QC and Chew CH (2013). Tumour necrosis factor alpha down-regulates the expression of peroxisome proliferator activated receptor alpha (PPARa) in human hepatocarcinoma HepG2 cells by activation of NF-κB pathway. Cytokine 61, 266–274. (ISI Thompson cited). (Research article is featured in “World Biomedical Frontiers - Cancer” (ISSN: 2328-0166) for its significant potential to improve health: July 2013)



Kor SB, Choo QC and Chew CH (2013). New integron gene arrays from multiresistant clinical isolates of Enterobacteriaceae and Pseudomonas aeruginosa from hospitals in Malaysia. Journal of Medical Microbiology 62(3), 412-420. (ISI Thompson cited).



Cheong HT, Ho WY, Choo QC and Chew CH (2014). β-lactamase gene blaSHV detected in bacteria isolated from retail sushi in Kampar, Malaysia. Biomedical Research 25 (1), 25-31. (ISI Thompson cited).



Kor SB, Tou BSY, Chieng CKL, Hiew MSY, Chew CH (2014). Distribution of the multidrug efflux pump genes adeA, adeI, adeJ, adeY and integrons in clinical isolates of Acinetobacter baumannii from Malaysian hospitals. Biomedical Research 25 (2): XX-XX (Accepted/ISI Thompson cited).

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CURRICULUM VITAE Local and International Conferences •

Chew CH, Lim WF, Lim WS, Choo QC, Tengku-Muhammad TS (2008). Cytokine regulation and signaling mechanisms targeting peroxisome proliferator activated receptor alpha in human HepG2 cell line. Chemistry and the Biosphere, University of Otago, New Zealand.



Cheng PS, Chew CH, Najimudin N, Choo QC (2008). Cultural independent characterisation and phylogeny of NifH genes from Malaysian Soil Environment. Chemistry and the Biosphere, University of Otago, New Zealand.



Kok YF, Choo QC, Chew CH (2008). Molecular cloning and expression of PPARα in human hepatocarcinoma HepG2 cell line. 19th Intervarsity Biochemistry Seminar: The Malaysian Society for Biochemistry and Molecular Biology (MSBMB) pg 64.



Yong KM, Choo QC, Chew CH (2008). A two-step RT-PCR approach for the detection of Pregnane-XReceptor (PXR), beta-actin and 18S ribosomal RNA (18S RNA) in liver carcinoma cells. 19th Intervarsity Biochemistry Seminar: The Malaysian Society for Biochemistry and Molecular Biology (MSBMB) pg 16.



Woo SF, Choo QC, Chew CH (2008). Detection of plasmids containing antibiotic resistance genes within natural populations of Tasik Sri Rampai. 19th Intervarsity Biochemistry Seminar: The Malaysian Society for Biochemistry and Molecular Biology (MSBMB) pg 58.



Tan SL, Chew CH, Choo QC (2008). Molecular diversity of nitrogen-fixing bacteria from Malaysian soil environment. 19th Intervarsity Biochemistry Seminar: The Malaysian Society for Biochemistry and Molecular Biology (MSBMB) pg 29.



Chong TM, Lai ML, Chew CH, Choo QC (2009). Molecular characterisation of TEM-type β-lactamases from ampicillin-resistant negative bacteria isolated from local vegetables. 20th Intervarsity Biochemistry Seminar (MSBMB), UPM.



Lim WS, Kor SB, Ng WL, Choo QC, Chew CH (2009). Real-Time RT-PCR profiling on NFKB2 and A20 mRNA expression from human hepatocarcinoma (HepG2) cell line. 20th Intervarsity Biochemistry Seminar (MSBMB), UPM. (Best Poster Presentation)



Leong MZ, Chew CH, Choo QC (2010). Diversity of nifH genes from unculturable microorganisms in the rhizosphere of Mimosa pigra on ex-tin mining land, 21st Intervarsity Biochemistry Seminar, UCSI.



Lao KM, Chew CH (2011). Effects of pro-inflammatory cytokines tumour necrosis factor alpha and interleukin-6 on ghrelin expression in rat pancreatic AR42J cell line. Malaysian Symposium on Biomedical Science 2011, IIUM Kuantan.



Lim SY, Lim SP, Tan WC, Choo QC, Chew CH (2011). Prevalence of Tetracycline Efflux Resistance Genes in Gram Negative Bacteria Isolated from Hospital Patients in Malaysia. 22nd Intervarsity Biochemistry Seminar, UKM.



Yu YE, Chew CH (2011). The effects of antioxidants kaempferol and ascorbic acid on Liver X Receptor alpha (LXR-α) in TNF-α stimulated human hepatocarcinoma HepG2 cells. 22nd Intervarsity Biochemistry Seminar, UKM.



Wong SY, Chew CH (2011). Molecular regulation and cytokine synergism studies of ghrelin expression in IFN-γ-treated rat pancreatic cell lines. 22nd Intervarsity Biochemistry Seminar, UKM.

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CURRICULUM VITAE •

Chen KK, Chew CH (2011). Effects of the flavanoid kaempferol on the expression of TNF-α induced NFkappaB1 and NF-kappaB2 activation in human hepatocarcinoma cell line. 22nd Intervarsity Biochemistry Seminar, UKM.



Ng DL, Tie SW, Lim WS, Tengku Muhammad TS, Choo QC, Chew CH (2011). Rapamycin pre-treatment followed by Tumour Necrosis Factor-α (TNF-α) stimulation up-regulates Lxr-α and Pxr expression in HepG2 cells. 1st National Postgraduate Conference in Molecular Medicine, Kota Bahru, Kelantan.



Lim WS, Tengku-Muhammad TS, Choo QC, Chew CH (2011). Inhibition of TNF-alpha-induced NFkappaB up-regulates PPARalpha mRNA expression in human hepatocarcinoma (HepG2) cell line. 1st National Postgraduate Conference in Molecular Medicine, Kota Bahru, Kelantan.



Wong HK, Chew CH (2012). Study on the effects of antioxidants on the expression of scavenger receptor class B type 1 (SRB1) in TNF-alpha treated human hepatocarcinoma HepG2 cell line. UTAR SCIENTIFIC MINI-SYMPOSIUM I (USMSI), Kampar, Perak.



Ho WY, Chew CH (2013). Molecular Epidemiology Of Community Acquired Methicillin Resistant Staphylococcus Aureus (Mrsa) In Kinta Valley. UTAR National Postgraduate Fundamental and Applied Sciences Seminar, UTAR, Perak.



Wong HK, Choo QC, Chew CH (2013). Investigation of the effects of Cocos nucifera milk on nuclear hormone receptors expression in human hepatocarcinoma cells. UTAR National Postgraduate Fundamental and Applied Sciences Seminar, UTAR, Perak.



Wong HK, Cheah HY, Chew CH (2013). Raw coconut milk and its active compound lauric acid abrogates TNF-alpha down-regulation of scavenger receptor class B type 1 (SRB1) expression. 20th MSMBB Annual Scientific Meeting, Universiti Malaya, Kuala Lumpur.

International DNA Database Publications •

Tan KY, Cheah HL, Najimudin N, Chew CH, Choo QC (2012). Uncultured bacterium clone pchl_w9 dinitrogenase reductase (nifh) gene, partial cds. (Genbank Acession Number JN217130.1).



Tan KY, Cheah HL, Najimudin N, Chew CH, Choo QC (2012). Uncultured bacterium clone pchl (b1, b4, b7, b15, b20 & b21) dinitrogenase reductase (nifh) gene, partial cds. (Genbank Acession Number JN217123.1-JN217128.1).



Tan KY, Cheah HL, Najimudin N, Chew CH, Choo QC (2012). Uncultured bacterium clone ptky1612_(3, 5,14,16) dinitrogenase reductase (nifh) gene, partial cds. (Genbank Acession Number JN217118.1, JN217116.1, JN217114.1, JN217112.1).



Tan KY, Cheah HL, Najimudin N, Chew CH, Choo QC (2012). Uncultured bacterium clone ptky2312_(1,3,8,10) dinitrogenase reductase (nifh) gene, partial cds. (Genbank Acession Number JN217104.1, JN217106.1, JN217108.1, JN217110.1).



Tan KY, Cheah HL, Najimudin N, Chew CH, Choo QC (2012). Uncultured bacterium clone ptky2312_(2, 7, 9) dinitrogenase reductase (nifh) gene, partial cds. (Genbank Acession Number JN217105.1, JN217107.1, JN217109.1).



Kor SB, Choo QC, Chew CH. (2012). Escherichia coli strain H35 class 1 integron aminoglycoside adenyltransferase (aadA2) and lincosamide nucleotidyltransferase (linF) genes, complete cds. National Center for Biotechnology Information (USA): (GenBank Accession Number JQ414042.1) Page 5

CURRICULUM VITAE •

Kor SB, Choo QC, Chew CH. (2012). Pseudomonas aeruginosa strain K17 class 1 integron aminoglycoside acetyltransferase (aac(3)Ic) and chloramphenicol resistance protein (cmlA5) genes, complete cds. National Center for Biotechnology Information (USA): (GenBank Accession Number JQ414040.1)



Kor SB, Choo QC, Chew CH. (2012). Morganella morganii strain G52 class 1 integron dihydrofolate reductase (dfrA17) and aminoglycoside adenylyltransferase (aadA5) genes, complete cds. National Center for Biotechnology Information (USA): (GenBank Accession Number JQ414038.1)



Kor SB, Choo QC, Chew CH. (2012). Pseudomonas aeruginosa strain K7 class 1 integron aminoglycoside 6'-N-acetyltransferase (aacA4), chloramphenicol acetyltransferase (catB8), and aminoglycoside 3'adenyltransferase (aadA1) genes, complete cds. National Center for Biotechnology Information (USA): (GenBank Accession Number JQ414041.1)



Kor SB, Choo QC, Chew CH. (2012). Morganella morganii strain G59 class 1 integron dihydrofolate reductase type I (dfrA1) and hypothetical protein (orfC) genes, complete cds. National Center for Biotechnology Information (USA): (GenBank Accession Number JQ414039.1)



Lim PS, Chew CH, Najimudin N and Choo QC (3-Jan-2011). Uncultured bacterium clone pPS204pPS244 dinitrogenase reductase (nifH) mRNA, partial cds, National Center for Biotechnology Information (USA): (GenBank Accession Number: FJ381614.1 - FJ381648.1) (35 sequences).



Lim PS, Chew CH, Najimudin N and Choo QC (30-Nov-2010). Uncultured bacterium clone pPS603, pPS611, pPS612, pPS614, pPS616 dinitrogenase reductase (nifH) mRNA, partial cds, National Center for Biotechnology Information (USA): (GenBank Accession Number: FJ469777.1 - FJ469773.1) (5 sequences).



Lim PS, Chew CH, Najimudin N and Choo QC (31-Oct-2009). Uncultured bacterium clone pPS435 dinitrogenase reductase (nifH) mRNA, partial cds, National Center for Biotechnology Information (USA): (GenBank Accession Number: FJ436219.1 - FJ436233.1) (17 sequences).



Lim PS, Chew CH, Najimudin N, Choo QC (25-Apr-2008). Uncultured bacterium clone dinitrogenase reductase (nifH) mRNA, partial cds, National Center for Biotechnology Information (USA): (GenBank Accession Number EU622626 - EU622628) (3 sequences).



Cheng PS, Chew CH, Najimudin N, Choo QC (30-Apr-2008). Uncultured bacterium clone dinitrogenase reductase (nifH) gene, partial cds, National Center for Biotechnology Information (USA): (GenBank Accession Number EU626502 - EU626518) (17 sequences).



Tan SL, Chew CH, Najimudin N, Choo QC (2008). Uncultured bacterium clone dinitrogenase reductase (nifH) gene, partial cds, National Center for Biotechnology Information (USA): (GenBank Accession Number EU626492 - EU626501) (10 sequences).



Chew CH, Najimudin N, Tengku-Muhammad TS (2006). Homo sapiens peroxisome proliferator-activated receptor alpha (PPARA) gene, promoter region D, exon 3 and partial cds, National Center for Biotechnology Information (USA): (GenBank Accession Number DQ867023).



Chew CH, Najimudin N, Tengku-Muhammad TS (2006). Homo sapiens peroxisome proliferator-activated receptor alpha (PPARA) gene, promoter region C and exon 2a, National Center for Biotechnology Information (USA): (GenBank Accession Number DQ867022).

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CURRICULUM VITAE •

Chew CH, Samian MR, Najimudin N, Tengku-Muhammad TS (2003). Homo sapiens peroxisome proliferator-activated receptor alpha (PPARA) gene, promoter B region and exon B, National Center for Biotechnology Information (USA): (GenBank Accession Number AY258332).



Chew CH, Samian MR, Najimudin N, Tengku-Muhammad TS. (2003). Homo sapiens peroxisome proliferator-activated receptor alpha (PPARA) mRNA, 5'UTR variants, National Center for Biotechnology Information (USA): (GenBank Accession Number AY258326 - AY258331) (6 sequences).

INTERNATIONAL AND NATIONAL SERVICE TO PROFESSION o

Manuscript reviewer for “THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY" journal (Oct 2012), PUBLISHER: ELSEVIER. International

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Manuscript reviewer for “MOLECULAR BIOLOGY REPORTS" journal (Nov 2012), PUBLISHER: SPRINGER. International

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External Reviewer of Research Proposal for “HIGH IMPACT RESEARCH (HIR) PROJECTS, UNIVERSITI MALAYA (MALAYSIA)” (Nov 2012). National

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SCIENTIFIC COMMITTEE AND EDITORIAL REVIEW BOARD ON MEDICAL AND BIOLOGICAL SCIENCE, WORLD ACADEMY OF SCIENCE, ENGINEERING AND TECHNOLOGY. International

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Manuscript reviewer for “CYTOKINE" journal (Feb 2013), PUBLISHER: ELSEVIER. International

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Manuscript reviewer for “CYTOKINE" journal (March 2013), PUBLISHER: ELSEVIER. International

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Manuscript reviewer for “THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY" JOURNAl" journal (July 2013), PUBLISHER: ELSEVIER. International

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External Reviewer of Research Proposal for “HIGH IMPACT RESEARCH (HIR) PROJECTS, UNIVERSITI MALAYA (MALAYSIA)” (Nov 2013). National

POSTGRADUATE SUPERVISION • • • • • • • • • • •

Ng Di Lin (MSc), Main supervisor, January 2008 - July 2011. Graduated Kor Sue Bee (MSc), Main supervisor, July 2009 - February 2012. Graduated Lim Wyi Sian (MSc), Main supervisor, August 2009 - March 2012. Graduated Chia Phee Phee (MSc), co-supervisor, May 2011 - current. On-going Ng Wei Ling (MSc), co-supervisor, February 2012 - current. Thesis under examination Cornelius Chieng Kwang Lee (MSc), co-supervisor, March 2012 - current. On-going Ho Wai Yew (MSc), Main supervisor, March 2012 – current. On-going Wong Hong Kin (MSc), Main supervisor, September 2012 – current. On-going Ong Sing Hui (MSc), co-supervisor, Dec 2012 – current. On-going Tie Shin Wei (MSc), Main supervisor, May 2013-current. On-going Melissa Ong Hui Ling (MSc), Main supervisor, registering

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