Wednesday, 12 October

Wednesday, 12 October 11:00 - 11:15 Identification of host E3 ligases targeting dengue virus O-17 nonstructural protein 4B using wheat cell-free based...

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Wednesday, 12 October

Wednesday, 12 October

8:30 - 9:00

9:00 - 12:15

DETAILED PROGRAM

9:00 - 9:15

Keynote Lecture 2 Molecular biology of flaviviruses

Alexander A KHROMYKH, U  niversity of Queensland, School of Chemistry and Molecular Biosciences, Australia

Session 2: Virus replication

Chairs: Ralf BARTENSCHLAGER & Sung Key JANG

Dissecting the requirements for Hepatitis C virus RNA synthesis using a split replication system

O-11

Lyudmila SHALAMOVA, Anika NIEDER-ROEHRMANN, Nadia DUENNES, Gesche GERRESHEIM, Steffen MUELLER, Yutong SONG, Eckard WIMMER, Oliver ROSSBACH, Michael NIEPMANN

9:15 - 9:30

miR-122 negatively regulates PCBP2-mediated circularization of the hepatitis C virus RNA genome

O-12

You LI, Oya BERMEK, Jack D GRIFFITH, Stanley M LEMON

9:30 - 9:45

G28A mutation is necessary for an efficient propagation of HCV in miR-122 deficient condition

O-13

Chikako ONO, Takasuke FUKUHARA, Daisuke MOTOOKA, Shota NAKAMURA, Satomi YAMAMOTO, Hiroyuki MORI, Kentaro UEMURA, Toru OKAMOTO, Su Su HMWE, Kazuaki CHAYAMA, Takaji WAKITA, Kazuhiko KOIKE, Yoshiharu MATSUURA

9:45 - 10:00

Affinity purification of the Hepatitis C virus replicase identifies Valosin-containing protein (VCP) AAA+ATPase as an active viral replication modulator

O-14

Zhigang YI, Caiyun FANG, Zhenghong YUAN

10:00 - 10:15

Sphingomyelin is a component in the membranous replication factories

O-15

Hossam E GEWAID, Haruyo AOYAGI, Koichi WATASHI, Ryosuke SUZUKI, Hussein ALY, Keigo KUMAJAI, Toshiyuki YAMAJI, Masayoshi FUKASAWA, Ayako MIMATA, Yuriko SAKAMAKI, Shizuko ICHINOSE, Kentaro HANADA, Takaji WAKITA, Hideki AIZAKI

10:15 - 10:30

Hepatitis C virus replication requires ribonucleotide reductase M2 to stabilize NS5B protein Bouchra KITAB, Masaaki SATOH, Masayuki SUDOH, Michinori KOHARA, Kyoko TSUKIYAMA-KOHARA

10:30 - 11:00 Refreshment Break

18 / HCV 2016

O-16

Wednesday, 12 October 11:00 - 11:15

Identification of host E3 ligases targeting dengue virus nonstructural protein 4B using wheat cell-free based-E3 protein array technology

O-17

Hirotaka TAKAHASHI, Youichi SUZUKI, Yuki SAMESHIMA, Subhash G VASUDEVAN, Naoki YAMAMOTO, Tatsuya SAWASAKI

11:15 - 11:30

Inosine Triphosphate Pyrophosphatase Enhances the Effect of Ribavirin on Hepatitis C Virus Cell Culture Infection

O-18

Kristina NYSTRÖM, Gustav PETTERSSON, Joanna SAID, Giorgia ORTOLANI, Sofia BRUNET, Jonas CARLSTEN, Paulina WANROOIJ, Ka-Wei TANG, Martin LAGGING

Dependence of Flavivirus replication on host Hsp70 chaperones provides an effective and resistance-free antiviral approach

O-19

Shuhei TAGUWA, Kelly RAINBOLT, Arabinda NAYAK, Jason GESTWICKI, Raul ANDINO, Judith FRYDMAN

11:45 - 12:00

Cyclooxygenase-2 facilitates dengue virus replication and serves as a potential target for developing antivirals

O-20

Chun-Kuang LIN, Chin-Kai TSENG, Yu-Hsuan WU, Chih-Chuang LIAW, Jin-Ching LEE

12:00 - 12:15

Let-7b induced by hepatitis C virus infection elicits dual effects on interferon responses of host cells

O-21

Yung-Ju YEH, Hsien-Da HUANG, Ching-Ping TSENG, Ju-Chien CHENG

12:15 - 12:30 Refreshment Break 12:30 - 13:20 Luncheon Seminar 1

Chair: ‌Kazuhiko KOIKE, Department of Gastroenterology, The University of Tokyo

Practical Therapy of Chronic Hepatitis C

Kazuaki CHAYAMA, D  epartment of Gastroenterology and Metabolism, Applied

Life Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University

Sponsored by Bristol-Myers Squibb K. K.

13:20 - 14:30 Lunch 14:30 - 15:00 Keynote Lecture 3 Pestiviruses - the not so well known rural cousins of HCV

Norbert TAUTZ, U  niversity of Luebeck, Institute for Virology and Cell Biology,

Germany

23rd International Symposium on Hepatitis C Virus and Related Viruses / 19

DETAILED PROGRAM

11:30 - 11:45

Wednesday, 12 October

15:00 - 16:30 Session 3: Viral assembly

Chairs: Masanori IKEDA & Brett LINDENBACH

15:00 - 15:15

N6-methyladenosine in the hepatitis C viral RNA genome regulates infection

O-22

Nandan S GOKHALE, Alexa BR MCINTYRE, Michael J MCFADDEN, Allison E RODER, Edward M KENNEDY, Sharon E HOPCRAFT, Kendra M QUICKE, Mariano A GARCIA-BLANCO, Matthew J EVANS, Sohail S SUTHAR, Shelton S BRADRICK, Christopher E MASON, Stacy M HORNER

15:15 - 15:30

The hepacivirus and pestivirus NS3 helicases act as motor proteins to power RNA encapsidation during virus particle assembly

O-23

DETAILED PROGRAM

Brett LINDENBACH, Jean NDJOMOU, Danilo DUBRAU, Feng YANG, Rudolf K. BERAN, Andrew KOHLWAY, Norbert TAUTZ, Anna M. PYLE

15:30 - 15:45

Hepatitis C virus (HCV) proteins interact with the ESCRT machinery via ubiquitination to facilitate viral envelopment

O-24

Rina BAROUCH-BENTOV, Gregory NEVEU, Fei XIAO, Melanie BEER, Elena BEKERMAN, Stanford SCHOR, Joseph CAMPBELL, Jim BOONYARATANAKORNKIT, Brett LINDENBACH, Albert LU, Yves JACOB, Shirit EINAV

15:45 - 16:00

Maturation of secreted hepatitis C virus particles by incorporation of Apoliporotein E enhances infectivity and partially protects from neutralizing antibodies

O-25

Thomas PIETSCHMANN, Dorothea BANKWITZ, Mandy DÖPKE, Kathrin HÜGING, Romy WELLER

16:00 - 16:15

Human cathelicidin can compensate the role of apolipoproteins in the formation of infectious HCV particles

O-26

Tomokazu TAMURA, Francesc PUIG-BASAGOITI, Takasuke FUKUHARA, Chikako ONO, Satomi YAMAMOTO, Hiroyuki MORI, Takeshi KURIHARA, Toru OKAMOTO, Yoshiharu MATSUURA

16:15 - 16:30

Unraveling the mode of action of the NS5A inhibitor Daclatasvir on HCV assembly Bertrand BOSON, Solène DENOLLY, Fanny TURLURE, Christophe CHAMOT, Marlène DREUX, François-Loïc COSSET

16:30 - 17:00 Refreshment Break 17:00 - 19:00 Poster Session 1

20 / HCV 2016

O-27