Wednesday, 12 October
Wednesday, 12 October
8:30 - 9:00
9:00 - 12:15
DETAILED PROGRAM
9:00 - 9:15
Keynote Lecture 2 Molecular biology of flaviviruses
Alexander A KHROMYKH, U niversity of Queensland, School of Chemistry and Molecular Biosciences, Australia
Session 2: Virus replication
Chairs: Ralf BARTENSCHLAGER & Sung Key JANG
Dissecting the requirements for Hepatitis C virus RNA synthesis using a split replication system
O-11
Lyudmila SHALAMOVA, Anika NIEDER-ROEHRMANN, Nadia DUENNES, Gesche GERRESHEIM, Steffen MUELLER, Yutong SONG, Eckard WIMMER, Oliver ROSSBACH, Michael NIEPMANN
9:15 - 9:30
miR-122 negatively regulates PCBP2-mediated circularization of the hepatitis C virus RNA genome
O-12
You LI, Oya BERMEK, Jack D GRIFFITH, Stanley M LEMON
9:30 - 9:45
G28A mutation is necessary for an efficient propagation of HCV in miR-122 deficient condition
O-13
Chikako ONO, Takasuke FUKUHARA, Daisuke MOTOOKA, Shota NAKAMURA, Satomi YAMAMOTO, Hiroyuki MORI, Kentaro UEMURA, Toru OKAMOTO, Su Su HMWE, Kazuaki CHAYAMA, Takaji WAKITA, Kazuhiko KOIKE, Yoshiharu MATSUURA
9:45 - 10:00
Affinity purification of the Hepatitis C virus replicase identifies Valosin-containing protein (VCP) AAA+ATPase as an active viral replication modulator
O-14
Zhigang YI, Caiyun FANG, Zhenghong YUAN
10:00 - 10:15
Sphingomyelin is a component in the membranous replication factories
O-15
Hossam E GEWAID, Haruyo AOYAGI, Koichi WATASHI, Ryosuke SUZUKI, Hussein ALY, Keigo KUMAJAI, Toshiyuki YAMAJI, Masayoshi FUKASAWA, Ayako MIMATA, Yuriko SAKAMAKI, Shizuko ICHINOSE, Kentaro HANADA, Takaji WAKITA, Hideki AIZAKI
10:15 - 10:30
Hepatitis C virus replication requires ribonucleotide reductase M2 to stabilize NS5B protein Bouchra KITAB, Masaaki SATOH, Masayuki SUDOH, Michinori KOHARA, Kyoko TSUKIYAMA-KOHARA
10:30 - 11:00 Refreshment Break
18 / HCV 2016
O-16
Wednesday, 12 October 11:00 - 11:15
Identification of host E3 ligases targeting dengue virus nonstructural protein 4B using wheat cell-free based-E3 protein array technology
O-17
Hirotaka TAKAHASHI, Youichi SUZUKI, Yuki SAMESHIMA, Subhash G VASUDEVAN, Naoki YAMAMOTO, Tatsuya SAWASAKI
11:15 - 11:30
Inosine Triphosphate Pyrophosphatase Enhances the Effect of Ribavirin on Hepatitis C Virus Cell Culture Infection
O-18
Kristina NYSTRÖM, Gustav PETTERSSON, Joanna SAID, Giorgia ORTOLANI, Sofia BRUNET, Jonas CARLSTEN, Paulina WANROOIJ, Ka-Wei TANG, Martin LAGGING
Dependence of Flavivirus replication on host Hsp70 chaperones provides an effective and resistance-free antiviral approach
O-19
Shuhei TAGUWA, Kelly RAINBOLT, Arabinda NAYAK, Jason GESTWICKI, Raul ANDINO, Judith FRYDMAN
11:45 - 12:00
Cyclooxygenase-2 facilitates dengue virus replication and serves as a potential target for developing antivirals
O-20
Chun-Kuang LIN, Chin-Kai TSENG, Yu-Hsuan WU, Chih-Chuang LIAW, Jin-Ching LEE
12:00 - 12:15
Let-7b induced by hepatitis C virus infection elicits dual effects on interferon responses of host cells
O-21
Yung-Ju YEH, Hsien-Da HUANG, Ching-Ping TSENG, Ju-Chien CHENG
12:15 - 12:30 Refreshment Break 12:30 - 13:20 Luncheon Seminar 1
Chair: Kazuhiko KOIKE, Department of Gastroenterology, The University of Tokyo
Practical Therapy of Chronic Hepatitis C
Kazuaki CHAYAMA, D epartment of Gastroenterology and Metabolism, Applied
Life Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University
Sponsored by Bristol-Myers Squibb K. K.
13:20 - 14:30 Lunch 14:30 - 15:00 Keynote Lecture 3 Pestiviruses - the not so well known rural cousins of HCV
Norbert TAUTZ, U niversity of Luebeck, Institute for Virology and Cell Biology,
Germany
23rd International Symposium on Hepatitis C Virus and Related Viruses / 19
DETAILED PROGRAM
11:30 - 11:45
Wednesday, 12 October
15:00 - 16:30 Session 3: Viral assembly
Chairs: Masanori IKEDA & Brett LINDENBACH
15:00 - 15:15
N6-methyladenosine in the hepatitis C viral RNA genome regulates infection
O-22
Nandan S GOKHALE, Alexa BR MCINTYRE, Michael J MCFADDEN, Allison E RODER, Edward M KENNEDY, Sharon E HOPCRAFT, Kendra M QUICKE, Mariano A GARCIA-BLANCO, Matthew J EVANS, Sohail S SUTHAR, Shelton S BRADRICK, Christopher E MASON, Stacy M HORNER
15:15 - 15:30
The hepacivirus and pestivirus NS3 helicases act as motor proteins to power RNA encapsidation during virus particle assembly
O-23
DETAILED PROGRAM
Brett LINDENBACH, Jean NDJOMOU, Danilo DUBRAU, Feng YANG, Rudolf K. BERAN, Andrew KOHLWAY, Norbert TAUTZ, Anna M. PYLE
15:30 - 15:45
Hepatitis C virus (HCV) proteins interact with the ESCRT machinery via ubiquitination to facilitate viral envelopment
O-24
Rina BAROUCH-BENTOV, Gregory NEVEU, Fei XIAO, Melanie BEER, Elena BEKERMAN, Stanford SCHOR, Joseph CAMPBELL, Jim BOONYARATANAKORNKIT, Brett LINDENBACH, Albert LU, Yves JACOB, Shirit EINAV
15:45 - 16:00
Maturation of secreted hepatitis C virus particles by incorporation of Apoliporotein E enhances infectivity and partially protects from neutralizing antibodies
O-25
Thomas PIETSCHMANN, Dorothea BANKWITZ, Mandy DÖPKE, Kathrin HÜGING, Romy WELLER
16:00 - 16:15
Human cathelicidin can compensate the role of apolipoproteins in the formation of infectious HCV particles
O-26
Tomokazu TAMURA, Francesc PUIG-BASAGOITI, Takasuke FUKUHARA, Chikako ONO, Satomi YAMAMOTO, Hiroyuki MORI, Takeshi KURIHARA, Toru OKAMOTO, Yoshiharu MATSUURA
16:15 - 16:30
Unraveling the mode of action of the NS5A inhibitor Daclatasvir on HCV assembly Bertrand BOSON, Solène DENOLLY, Fanny TURLURE, Christophe CHAMOT, Marlène DREUX, François-Loïc COSSET
16:30 - 17:00 Refreshment Break 17:00 - 19:00 Poster Session 1
20 / HCV 2016
O-27
