Your Way of qPCR

the presence of the existing target sequence in real time. The key features of this detection method are outstanding high-performance optics as well a...

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Real-Time PCR

Your Way of qPCR qTOWER3 Product Family

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qTOWER3 Product Family Redefining excellence: The qTOWER³ product family sets new standards of flexibility and precision – for all real-time PCR applications. The quantitative polymerase chain reaction (qPCR) is an established method for the highly sensitive detection and quantification of DNA or RNA. The measuring principle is based on fluorescent signals, which, cycle by cycle, capture the presence of the existing target sequence in real time. The key features of this detection method are outstanding high-performance optics as well as excellent temperature uniformity over 96 or up to 384 samples. The qTOWER³ product family guarantees well-founded real-time PCR results as it benefits from peerless temperature control precision in the sample block regardless of the number of samples used. The patented high-performance optics guarantee the outstanding homogeneous excitation and illumination of all individual samples. The qTOWER³ product family achieves unique flexibility with its proven filter module equipment, which can be freely configured and expanded at any time, and enables up to six-fold multiplexing.

qTOWER3 84

qTOWER3 Product Family Your Way of qPCR

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qTOWER3 touch qTOWER3

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qTOWER3 See, marvel, experience: The performance of the new realtime PCR thermal cycler qTOWER³ impresses across the board. The patented fiber-optic shuttle system with its unique light source, composed of four high-performance LEDs, guarantees the ideal excitation of known fluorescent dyes up to the deep red range. In the process, the detection module can accept up to six different color filter modules. The retrofitting option ensures that users can also integrate future innovative developments from Analytik Jena. The proven silver block technology of the qPCR cycler offers outstanding control precision of ± 0.1 °C over the entire 96 well block in 0.2 ml format. Thanks to the gradient function, the device can be optimally adapted to new assays. The qTOWER³ is available either as a stand-alone device with integrated touchscreen operation (10“) or as a computer-aided system. The software contains a broad spectrum of optimized analysis algorithms, including absolute and relative quantification, ddCt method, PCR efficiency, allelic discrimination, end-point detection, and melting curve and protein analysis.

qTOWER3 Get in touch with High-Class qPCR

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qPCRsoft Package

Maximum Flexibility

Ideal Real-Time PCR Signals

Optimal Thermal Conductivity

qPCRsoft Package for Convenient Control and Operation ■■ Convenient: Stand-alone operation via integrated tablet control (10“) and/or comprehensive PC control ■■ Transparent: No costs for software licenses or updates ■■ Universal: Covers the entire spectrum from a simple representation of Ct values to the ddCt method and multiplate analysis ■■ Multilingual: Available in multiple languages, including German Expandable Filter Module System for Maximum Flexibility ■■ Practical: The twelve color, FRET, and protein modules can be retrofitted or exchanged within five minutes ■■ Future-proof: Thanks to new filter modules, adaptable to new applications at any time ■■ Durable: 10-year long-term guarantee for high-performance optical components

Patented Fiber-optic System for Ideal Real-Time PCR ■■ Efficient: Minimal scan times of 6 seconds for up to six-fold multiplexing ■■ Innovative: New light source with four long-stability LEDs (RGWB) with no preheating time and a long service life ■■ Brilliant: Ideal illumination and excitation of all 96 samples with no edge effects High-Quality Silver Sample Block for Optimal Thermal Conductivity ■■ Fast: Heating rates of 8 °C/s, cooling rates of 6 °C/s ■■ Unrivaled: Ideal temperature homogeneity and unmatched control precision (± 0.1 °C) ■■ Precise: Programming of integer temperatures from column to column of the 96 well sample block using the Linear Gradient Tool (max. range 40 °C).

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Patented Fiber-Optic Shuttle System For the ideal reproducibility and maximum data security of all real-time PCR results, the integrated high-performance optics guarantee the homogeneous excitation of each individual sample and the reliable recording of the emitted fluorescent signals.

In the application area of quantitative real-time PCR, a wide range of fluorescent dyes with different characteristics are used. In order to optimally excite each of these dyes across a large spectrum, the qTOWER³ has a light source with four different-colored, long-life LEDs (RGBW). This ensures that each dye used in a real-time PCR experiment achieves the best possible quantum yield.

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 atented high-performance optics with eight optical P fibers and four different-colored LEDs Optimal homogeneous excitation and detection in each of the 96 wells Special plus: Read-out of a 96 well microplate in just 6 seconds – regardless of the number of dyes No edge effects – no need for a passive reference

Special, highly sophisticated multiplex applications with up to six fluorescent-labeled probes from blue to the nearinfrared range can be handled without difficulty. Fiberoptic system (FOS): The optical unit from a shuttle system with eight high-performance fibers ensures an extremely fast read-out from the 96 well plate in just 6 seconds – regardless of the number of dyes to be measured. All components of the high-performance fiber optics have a 10-year long-term guarantee.

Maximum Flexibility The color filter equipment of the qTOWER³ family can be freely configured and, depending on the application, can also be adapted to intercalating or protein-binding dyes and hydrolysis and hybridization probes (FRET probes). The retrofitting option makes the device system particularly future-proof: Additional color, FRET, or protein modules can be integrated at any time to further expand the range of applications. All the various filter modules contain an optimized combination of excitation and emission filters which, in combination with the light source, enables the ideal detection of a large number of commercially available fluorescent dyes.

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Freely configurable selection of color filters Can accept up to six different color, FRET, or protein modules Use of intercalating dyes, hydrolysis or hybridization probes, and protein-binding dyes

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Innovative Silver Block Technology Aside from the optical components for the detection of real-time signals, amplification plays a key role in real-time PCR. More than 25 years of experience in the field of thermal cyclers offer the promise of first-class quality with the qTOWER³.

The sample block forms the basis for the reliable performance of quantitative real-time PCR in the qTOWER³ and the qTOWER³ touch. To ensure the best-possible results and an outstanding transfer of energy to the sample, the thermal block is made of gold-coated silver. As a result, the qTOWER³ is distinguished by excellent temperature control precision of ± 0.1 °C (over 96 wells) and first-class heating rates of up to 8 °C/s. This combination makes the entire system absolutely ideal for any real-time PCR application.

To ensure the highest specificity for different assays, the device is equipped with a gradient function with a spread of up to 40 °C. Instead of simply setting lower and upper limits, the Linear Gradient Tool (LGT) allows different integer temperature levels to be entered in relation to the calculated annealing temperature of the primers – further evidence of the simple, intuitive operation of the qTOWER³. The open platform makes it possible to use low profile (0.1 ml) and standard profile (0.2 ml) plastic. Non-, semi- and full-skirted qPCR plates can likewise be used.

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 uantitative real-time PCR in the proven 0.2 ml Q format with 96 wells Innovative silver block with outstanding ramping rates of up to 8 °C Excellent temperature control of ± 0.1 °C across the entire sample block Gradient function over 12 columns with a 40 °C spread using linear programming (Linear Gradient Tool)

To avoid condensation and the resulting loss of samples, the device system is fitted with a motorized heated lid. This can be variably set to up to 110 °C and guarantees optimal contact pressure on the sample vessels throughout the real-time PCR run, regardless of the consumable used.

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Intuitive Operation and Automatic Analysis The qTOWER³ can be intuitively and easily controlled both through a desktop PC or laptop and by means of an integrated tablet. A comprehensive package of individual analysis methods and helpful additional functions complete the entire system.

The qPCRsoft control and analysis software proves itself to be flexible and user-friendly. The logical, clear arrangement of all the tools, the intuitive handling, and last but not least the parameter-oriented memory and programming concept make the software easier to use. During a live run, the data from previous experiments can be simultaneously analyzed without difficulty.

qPCRsoft

To ensure that operation is as simple as possible, many of the steps occur automatically – such as threshold calculation for determining Ct values or possible standard curves and PCR efficiencies. Further analyses can likewise be conducted automatically, such as absolute or relative quantifications, or the ddCt method (with or without reference to PCR efficiency). qPCRsoft also includes analysis methods for probe-based, allelic discrimination, e.g. for the identification of point mutations and the use of a positive/negative analysis via the end-point detection of samples.

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 PCRsoft: User-friendly and q clearly structured Integrated analysis algorithms: Absolute and relative quantification, ddCt method, genotyping, endpoint detection, and melting curve, protein, and multiplate analysis. User administration with three authorization levels MIQE-compliant documentation License-free, free updates

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qPCRsoft touch.

Get in touch with qTOWER³ The strong performance of the qTOWER³ can optionally be supplemented by a highly innovative operation concept. The qTOWER³ touch is a modern stand-alone system that does not require any external control. The integrated 10“ tablet leaves nothing to be desired when it comes to planning and conducting experiments. The touchscreen operation impresses with its simple, intuitive menu navigation which enables cycler programming, online monitoring, and the final determination of Ct values. The data files are compatible with the comprehensive PC software at all times and allow subsequent analyses to be conducted without difficulty.

Regardless of whether it is the qTOWER³ or the qTOWER³ touch – the real-time PCR thermal cyclers from Analytik Jena are ideal and reliable tools for everyday laboratory work.

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Impressive Performance – qTOWER3 The combination of unique optics and a high-quality silver block with incomparably precise temperature control ensures ideal amplification results. This makes the qTOWER³ an unbeatable partner for quantitative real-time PCR applications.

Fig. 1: Amplification of 10 orders of magnitude with automatical determination of the standard curve including important parameters like R² and PCR efficiency.

Logarithmic view

Standard curve

The example of human genomic DNA amplification shows an optimal linearity over 10 orders of magnitude from 109 to 100 copies. Accordant PCR efficiency of 100 % with R² > 0.999 was automatically determined by qPCRsoft.

Fig. 2: Amplification of an E.coli specific target sequence in 96 wells. The main ct value of 12.99 with a standard de­via­tion of 0.07 was determined automatically.

Linar view

Logarithmic view

The single excitation and detection of each well avoids the often observed edge effects and allows excellent, homogeneous amplification plots over the entire 96 well block with a standard deviation below 0.07.

Fig. 3: Examination of 9 patients with the FTD ACE diagnostic kit. The calculation of the viral load is performed automatically by generating a standard curve.

Linar view

Melting curve analysis

The flexible filter configuration of qTOWER³ ensures verifications of a broad spectra of application fields, e.g. the Fast-Track ACE Kit for detection of adenovirus, cytomegalovirus, Epstein-Barr virus and internal control.

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qTOWER3 84 Enhance Your Throughput – A New Standard for Speed and Precision in High-throughput qPCR With steadily growing sample volumes and new options for molecular biology experiments, the requirements for quantitative real-time PCR are changing. The transition to the multiwell format with 384 samples opens up new application areas in gene expression, mutation analysis, and diagnostics. The qTOWER3 84 includes all of the strengths of the qTOWER3 product family and transfers its precise performance to the 384 well high-throughput format. The proven high-performance optics have been expanded to 16 fibers and enable an ultra-fast read-out time of just 6 seconds for a complete 348 well plate – regardless of the number of filters used. Here, too, the system benefits from the complete flexibility of freely configurable filter equipment, allowing it to be adapted to any application. The innovative light source with four different-colored LEDs also enables read-outs of very small sample volumes, which play an increasingly important role in the high-throughput format along with existing factors like speed and experimental precision. The high-quality aluminum block guarantees precise, accurate conductivity combined with unmatched temperature uniformity across the entire sample set. A peerless feature of the qTOWER³ 84 G is the gradient over a total of 24 columns, which can be programmed using the proven Linear Gradient Tool. The license-free, comprehensive qPCRsoft package completes the system, and a detailed analysis can be easily obtained even in the 384 well format thanks to analysis algorithms which are already integrated.

qTOWER3 84 The next Level of qPCR

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qPCRsoft Package for Convenient Control and Operation ■■ Convenient: Comprehensive PC control ■■ Transparent: No costs for software licenses or updates ■■ Universal: Covers the entire spectrum from a simple representation of Ct values to the ddCt method and multiplate analysis ■■ Multilingual: Available in multiple languages, including German

Patented Fiber-optic System for Ideal Real-Time PCR ■■ Efficient: Minimal scan times of 6 seconds for up to six-fold multiplexing ■■ Innovative: New light source with four long-stability LEDs (RGWB) with no preheating time and a long service life ■■ Brilliant: Ideal illumination and excitation of all 384 samples with no edge effects

Expandable Filter Module System for Maximum Flexibility ■■ Practical: The twelve color, FRET, and protein modules can be retrofitted or exchanged within five minutes ■■ Future-proof: Thanks to new filter modules, adaptable to new applications at any time ■■Durable: 10-year long-term guarantee for high-performance optical components

High-Quality Aluminium Sample Block for Optimal Thermal Conductivity ■■ State-of-the-Art: Heating rates of 4 °C/s, cooling rates of 2 °C/s ■■ Unrivaled: Ideal temperature homogeneity and unmatched control precision (± 0.1 °C) ■■ Precise: Programming of integer temperatures for 24 columns of the 384-well sample block using the Linear Gradient Tool (max. range 24 °C).

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High-Performance System for High Throughput The qTOWER³ 84 achieves the next level of a powerful DNA detection system by increasing qPCR throughput while simultaneously miniaturizing individual reactions. The centerpiece of the device is extremely precise and reliable temperature control, together with optical signal recognition for all 384 samples that are used for qualitative and quantitative DNA characterization. The proven fiber-optic shuttle system in the qTOWER³ has been perfectly adapted to the 384 well format and expanded to 16 scanning fibers. In combination with an outstanding, long-life source of light from four different LEDs, an extremely fast read-out of the fluorescences in just six seconds is guaranteed for a complete 384 well plate with up to six-fold multiplexing.

The 384 well aluminum block with its excellent temperature uniformity is the foundation of the qTOWER³ 84 and is indispensable for the extremely precise and reliable amplification of PCR products. These reaction parameters guarantee the high specificity and yield of the reaction and are directly related to the speed and precision of the result. The excellent control precision of the sample block ensures homogeneous heat distribution across all the wells of a plate, which ultimately means the highest possible reproducibility from well to well and from cycle to cycle.

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 atented high-performance optics with 16 optical P fibers and four different-colored LEDs Optimal homogeneous excitation and detection in each of the 384 wells Special plus: Read-out of a 384 well microplate in just 6 seconds – regardless of the number of dyes No edge effects – no need for a passive reference

 uantitative real-time PCR in the high-throughput Q format with 384 wells Proven aluminum block with outstanding ramping rates of up to 4 °C Excellent temperature uniformity of ± 0.15 °C across the entire sample block Gradient function over 24 columns with a 24 °C spread using linear programming (Linear Gradient Tool)

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Complete System – Everything from a Single Source – Sample Processing at the Highest Level Precise results for quantitative real-time PCR in high-throughput format with 384 samples require an accurate sample setup, which involves substantial time and effort. Meet Your Throughput Needs To standardize and improve the precision and reproducibility of real-time PCR reactions, the use of a pipetting robot is recommended. With its large number of liquid-handling systems, Analytik Jena offers the perfect solution for daily pipetting routines.

For example, GeneTheatre greatly simplifies all pending pipetting tasks in the laboratory and allows for full automation. The standardization of processes significantly reduces errors with reactions involving 10 or 5 microliter batch volumes – regardless of the experience and skill of the user. In combination with its qTOWER³ 84, as well as its diverse reagent portfolio as a further option, Analytik Jena offers a customized complete system here that can be tailored to individual application, throughput, and capacity requirements.

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Impressive Performance - qTOWER3 84 The reliable device technology ensures a convincing demonstration of real-time PCR results in 384 well format. In addition to the lightning read-out speed the qTOWER³ 84 represents the right choice for high-troughput real-time PCR application.

Fig. 1: Amplification of an E. coli specific target gene sequence in 384 wells. The main Ct value of 13.37 with a standard deviation of 0.18 was determined automatically

Linear view

Logarithmic view

The single excitation and detection of each well avoids the often observed edge effects and allows excellent, homogeneous amplification plots over the entire 384 well block.

Fig. 2: Amplification of 5 µl 10 µl, 15 µl and 20 µl qPCR reactions volume. By using qPCRsoft a main Ct value of 26.22 + 0,07 and a main melting point of 79.88 + 0,08 °C was determined.

Linear view

Melting curve analysis

Also regarding to the used PCR reaction volume the qTOWER³ shows an enourmous capacity. In a range of 5 µl to 20 µl a standard deviation of only 0.07 for Ct values and 0.08 °C for melting temperature can be achieved.

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Technical Data qTOWER3/qTOWER3 touch

qTOWER3 84

Thermal block

Silver sample block with gold coating

Aluminum, special alloy

Block capacity

96 wells in 0.2 ml format

384 wells

Sample volume

5 - 80 µl

2 - 30 µl (5 - 20 µl recommended)

Heating

8 °C/s

4 °C/s

Cooling

6 °C/s

2 °C/s

Temperature setting range

4 - 99 °C

Temperature control precision

± 0.1 °C

Temperature uniformity Max. / min. gradient

55 °C ± 0.15 °C after 15 sec qTOWER³ G and qTOWER³ G touch: 40 °C/0.1 °C

qTOWER³ 84 G: 24 °C/0.1 °C

Heated lid Lid temperature

30 °C to 110 °C

Contact pressure

30 kg, automated

qPCR application Sensitivity

1 copy of the target sequence

Dynamic range

10 log levels

Optics Measuring principle

Fiber-optic shuttle system with 8-fold scanner and filter modules

Fiber-optic shuttle system with 16-fold scanner and filter modules

Light source

4 long-life, high-performance LEDs (RGBW)

Detector

Highly sensitive PMT (photo multiplier tube)

Color modules Read-out time

12 color, FRET, and protein modules 6 positions in the device 6 seconds for 96 wells regardless of the number of filters

6 seconds for 384 wells regardless of the number of filters

Choice between PC or stand-alone version qTOWER³ touch: 10” tablet, color

PC software

Operation Software Dimensions Weight Size (width x height x depth)

30 kg 275 mm x 585 mm x 275 mm

Additional technical data Interfaces

Noise emission Warranty

PC connection: USB Tablet: USB for data transfer, barcode reader

PC connection: USB

45 db 2 years warranty on device system 10 years long-term warranty on high performance optics

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Order Information Parameters color module Description/Order number

Excitation

Emission

Example fluorescent dyes*

Color module 1, Order number: 844-00520-0

470 nm

520 nm

FAMTM, Sybr®Green, Alexa488®

Color module 2, Order number: 844-00521-0

515 nm

545 nm

JOE TM, HEX TM, VIC®, YakimaYellow®

Color module 3, Order number: 844-00522-0

535 nm

580 nm

TAMRATM, DFOTM, Alexa546®, NEDTM

Color module 4, Order number: 844-00523-0

565 nm

605 nm

ROX TM, TexasRed®, Cy3.5®

Color module 5, Order number: 844-00524-0

630 nm

670 nm

Cy5®, Alexa633®, Quasar670TM

Color module 6, Order number: 844-00525-0

660 nm

705 nm

Cy5.5®, LightCycler Red®

FRET module 1, Order number: 844-00526-0

470 nm

580 nm

FAMTM (donor) / TAMRATM (acceptor)

FRET module 2, Order number: 844-00527-0

470 nm

670 nm

FAMTM (donor) / Cy5® (acceptor)

FRET module 3, Order number: 844-00528-0

470 nm

705 nm

FAMTM (donor) / Cy5.5® (acceptor)

FRET module 4, Order number: 844-00529-0

515 nm

670 nm

JOE TM (donor) / Cy5® (acceptor)

FRET module 5, Order number: 844-00531-0

470 nm

605 nm

FAMTM (donor) / ROXTM (acceptor)

Color modul Protein 1, Order number: 844-00530-0

490 nm

580 nm

SYPRO® Orange

* The Color or FRET modules can be ordered separately. The qTOWER3/84 can be equipped with up to 6 modules. Yakima Yellow is registered trademark of Epoch Biosciences, Inc. Cy is a trademark of GE Healthcare. FAM, HEX, JOE, VIC, TAMRA, NED and ROX are trademarks of Applera Corporation or its subsidiaries in the US and/or certain other countries. SYBR, Alexa Fluor, SYPRO and Texas Red are registered trademarks of Molecular Probes, Inc. TaqMan and LightCycler are registered trademarks of Roche Group, Inc. Quasar Dyes are trademarks of Biosearch Technologies Inc. DFO™ is a trademark of Eurogentec S.A. Windows and Excel are trademarks of Microsoft Corporation.

Corresponding Products Order number

Description

Order number

Description

845-AS-1310100

innuMIX qPCR SyGreen Sensitive - 100 reactions

845-AS-1900100

innuDRY qPCR MasterMix Probe - 100 reactions

845-AS-1310200

innuMIX qPCR SyGreen Sensitive - 200 reactions

845-AS-1900200

innuDRY qPCR MasterMix Probe - 200 reactions

845-AS-1310500

innuMIX qPCR SyGreen Sensitive - 500 reactions

845-AS-1901000

innuDRY qPCR MasterMix Probe - 1000 reactions

845-AS-1320100

innuMIX qPCR DSGreen Standard - 100 reactions

845-AS-1200100

innuMIX qPCR MasterMix Probe - 100 reactions

845-AS-1320200

innuMIX qPCR DSGreen Standard - 200 reactions

845-AS-1200200

innuMIX qPCR MasterMix Probe - 200 reactions

845-AS-1320500

innuMIX qPCR DSGreen Standard - 500 reactions

qPCR reagents

Plastics and Accessories 844-70036-0

96 Well PCR Plate (0.2 ml; HP), non-skirted, white - 100 pieces

844-70037-0

96 Well PCR Plate (0.2 ml; HP), half-skirted, white - 100 pieces

844-70038-0

96 Well PCR Plate (0.2 ml; LP), full-skirted, white- 100 pieces

844-70045-0

Optical sealing foil (77 x 140 mm), transparent, peeling - 100 pieces

844-70086-0

Optical sealing foil (77 x 140 mm), adhesive, transparent, peeling able - 100 pieces

844-70087-0

8 Well Strip (0.2 ml; HP), white without lid - 120 pieces

847-0501001102

RoboStrip® 8 well strip low profile (0.1 ml) polypropylene white incl. sealing foil - 125 Strips

qTOWER³ Product Family To Fit Your Laboratory Needs qTOWER³ Product Family

qTOWER³

qTOWER³ G

qTOWER³ touch

qTOWER³ G touch

qTOWER³ 84

qTOWER³ 84 G

Order number

844-00553-2 Base unit incl. Color module 1

844-00554-2 Base unit incl. Color module 1

844-00555-2 Base unit incl. Color module 1

844-00556-2 Base unit incl. Color module 1

844-00508-2 Base unit

844-00509-2 Base unit

Sample block

Silver sample block with gold coating

Silver sample block with gold coating

Silver sample block with gold coating

Silver sample block with gold coating

Aluminum block special alloy

Aluminum block special alloy

Block capacity

96 wells in 0.2 ml format

96 wells in 0.2 ml format

96 wells in 0.2 ml format

96 well à 0.2 ml

384 wells

384 wells

Reaction volume

5 - 80 µl

5 - 80 µl

5 - 80 µl

5 - 80 µl

2 - 30 µl (5 - 20 µl recommended)

2–30 µl (5 - 20 µl recommended)

Heating

Max. 8 °C/s

Max. 8 °C/s

Max. 8 °C/s

Max. 8 °C/s

Max. 4 °C/s

Max. 4 °C/s

Cooling

Max. 6 °C/s

Max. 6 °C/s

Max. 6 °C/s

Max. 6 °C/s

Max. 2 °C/s

Max. 2 °C/s

Temperature uniformity

55 °C ± 0.15 °C after 15 s

55 °C ± 0.15 °C after 15 s

55 °C ± 0.15 °C after 15 s

55 °C ± 0.15 °C after 15 s

55°C ± 0.15 °C after 15 s

55 °C ± 0.15 °C after 15 s

Gradient

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0.1 °C - 40 °C over 12 columns Linear Gradient Tool

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0.1 °C - 40 °C over 12 columns Linear Gradient Tool

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0.1 °C - 24 °C over 24 columns Linear Gradient Tool

Control

qPCRsoft package for PC

qPCRsoft package for PC

Stand-alone version with 10” touchscreen display incl. qPCRsoft package for PC

Stand-alone version with 10” touchscreen display incl. qPCRsoft package for PC

qPCRsoft package for PC

qPCRsoft package for PC

Filter configuration

Flexible filter configuration: 6 positions in the device

Flexible filter configuration: 6 positions in the device

Flexible filter configuration: 6 positions in the device

Flexible filter configuration: 6 positions in the device

Flexible filter configuration: 6 positions in the device

Flexible filter configuration: 6 positions in the device

Analytik Jena AG Konrad-Zuse-Str. 1 07745 Jena · Germany Phone +49 3641 77 70 Fax +49 3641 77 9279 [email protected] www.analytik-jena.com

Pictures: Analytik Jena AG Subject to changes in design and scope of delivery as well as further technical development.

en · 09/2018 · 844-MA146-2-B Förster & Borries GmbH & Co. KG © Analytik Jena AG

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